McKay E J, Haines D J
N Z Med J. 1978 May 10;87(611):315-8.
A selection of patients with nephritis and collagen diseases were studied for complement abnormalities. This communication briefly reviews the current comcepts of complement physiology, details standard assay used in this laboratory and describes clinical examples where these tests have provided significant clinical information. Quantitative measurements of individual components, the presence of circulating immune complexes, and the demonstration of in vivo C3 cleavage products were assessed simultaneously. The importance of measuring cleavage products and immune complexes is stressed. Clinical examples are given where misleading or erroneous interpretation of results might have occurred if these tests had not been performed.
对一组肾炎和胶原病患者进行了补体异常研究。本报告简要回顾了补体生理学的当前概念，详述了本实验室使用的标准检测方法，并描述了这些检测提供重要临床信息的临床实例。同时评估了各个补体成分的定量测定、循环免疫复合物的存在以及体内C3裂解产物的检测。强调了检测裂解产物和免疫复合物的重要性。给出了临床实例，说明如果未进行这些检测可能会出现对结果的误导性或错误解读。
