Bağcılar Teaching Hospital, Estambul, Turquía.
Chest Diseases, Medical Faculty, Medipol University, Estambul, Turquía.
Arch Bronconeumol. 2017 Mar;53(3):107-113. doi: 10.1016/j.arbres.2016.05.021. Epub 2016 Sep 23.
Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease (CVD). Red blood cell distribution width (RDW) is accepted as a powerful predictor of outcomes in patients with CVD.
To study RDW in patients with COPD, and to compare the value of this measurement with clinical, echocardiographic, nutritional and laboratory status. Secondly, we aimed to determine the effect of smoking on RDW values in healthy subjects.
One hundred and seventy-five patients with stable COPD and 210 healthy controls were enrolled in the study. Demographic, clinical, nutritional status, echocardiographic, and laboratory characteristics, RDW values were recorded and compared.
RDW values were higher in the COPD group than in controls (15±2.3% vs. 13.8±2.5%, p<0.001). In COPD patients, RDW levels positively correlated with CRP levels (r=0.27, P<.001), albumin levels (r=0.23, P=.04), right ventricular dysfunction (RVD) (r=0.24, P=.001), pulmonary hypertension (PAH) (r=0.1, P=.02), and presence of CVD (r=0.24, P=.02). In multivariable logistic regression suggested that presence of CVD (4.3; 95% CI: 1.3 to 11; P=.01), and presence of RVD (3.1; 95% CI: 1.7 to 8.3; P=.02) were independently related to elevated RDW levels in COPD patients. In the healthy population, correlations analysis showed only a significant correlation between RDW and cigarette smoking years (r=0.57, P<.001).
RDW is independently associated with CVD and RVD in patients with COPD. In the healthy population, RDW is also associated with smoking status.
慢性阻塞性肺疾病（COPD）增加了心血管疾病（CVD）的风险。红细胞分布宽度（RDW）被认为是 CVD 患者预后的有力预测指标。
研究 COPD 患者的 RDW，并比较该测量值与临床、超声心动图、营养和实验室状态的价值。其次，我们旨在确定吸烟对健康受试者 RDW 值的影响。
纳入 175 例稳定期 COPD 患者和 210 例健康对照者。记录并比较人口统计学、临床、营养状况、超声心动图和实验室特征、RDW 值。
COPD 组的 RDW 值高于对照组（15±2.3% vs. 13.8±2.5%，p<0.001）。在 COPD 患者中，RDW 水平与 CRP 水平呈正相关（r=0.27，P<.001）、白蛋白水平（r=0.23，P=.04）、右心室功能障碍（RVD）（r=0.24，P=.001）、肺动脉高压（PAH）（r=0.1，P=.02）和 CVD 的存在（r=0.24，P=.02）。多变量逻辑回归提示 CVD 的存在（4.3；95% CI：1.3 至 11；P=.01）和 RVD 的存在（3.1；95% CI：1.7 至 8.3；P=.02）是 COPD 患者 RDW 升高的独立相关因素。在健康人群中，相关性分析仅显示 RDW 与吸烟年限之间存在显著相关性（r=0.57，P<.001）。
RDW 与 COPD 患者的 CVD 和 RVD 独立相关。在健康人群中，RDW 也与吸烟状况有关。
