Mather S J, Tolley D M, White G W
Department of Nuclear Medicine, St. Bartholomews Hospital, London, UK.
Eur J Nucl Med. 1989;15(6):307-12. doi: 10.1007/BF00435471.
Using the cyclic DTPA derivatisation procedure developed by Hnatowich, conditions have been optimised for labelling three tumour-associated monoclonal antibodies with 90Y. High labelling efficiencies (greater than 95%) at modest specific activities (1 mCi/mg) could be routinely obtained. Radiochemical stability of the radiolabelled preparations in vitro was good, but radiolysis resulted in early losses of antibody immunoreactivity.
