Wissenschaftliches Institut, Klinik Bavaria Kreischa, , Germany.
J Rehabil Med. 2016 Oct 12;48(9):793-798. doi: 10.2340/16501977-2135.
To describe the time course of recovery of sit-to-stand function in patients with intensive-care-unit-acquired muscle weakness and the impact of recovery.
A cohort study in post-acute intensive care unit and rehabilitation units. Patients with chronic critical illness and intensive-care-unit-acquired muscle weakness were included. Sit-to-stand function was measured daily, using a standardized chair height, defined as 120% of the individual's knee height.
A total of 150 patients were recruited according to the selection criteria. The primary outcome of independent sit-to-stand function was achieved by a median of 56 days (interquartile range Q1-Q3 = 32-90 days) after rehabilitation onset and a median of 113 days (Q1-Q3=70-148 days) after onset of illness. The final multivariate model for recovery of sit-to-stand function included 3 variables: age (adjusted hazard ratio (HR) = 0.96 (95% CI 0.94-0.99), duration of ventilation (HR=0.99 (95% CI 0.98-1.00) and Functional Status Score for the Intensive Care Unit (FSS-ICU) (adjusted HR=1.12 (95% CI 1.08-1.16)).
Rapid recovery of sit-to-stand function for most patients with intensive-care-unit-acquired muscle weakness were seen. The variables older age and longer duration of ventilation decreased, and higher FSS-ICU increased the chance of regaining independent sit-to-stand function.
描述 ICU 获得性肌无力患者从坐位到站立位功能恢复的过程及其影响。
这是一项在 ICU 后和康复病房进行的队列研究。纳入患有慢性危重病和 ICU 获得性肌无力的患者。使用标准化椅子高度（定义为个体膝盖高度的 120%）每天测量坐位到站立位的功能。
根据入选标准共招募了 150 名患者。康复开始后中位数 56 天（四分位距 Q1-Q3=32-90 天）、发病后中位数 113 天（Q1-Q3=70-148 天）达到独立坐位到站立位功能的主要结局。坐位到站立位功能恢复的最终多变量模型包括 3 个变量：年龄（校正后的危险比（HR）=0.96（95%置信区间 0.94-0.99）、通气时间（HR=0.99（95%置信区间 0.98-1.00）和 ICU 功能状态评分（FSS-ICU）（校正 HR=1.12（95%置信区间 1.08-1.16））。
大多数 ICU 获得性肌无力患者的坐位到站立位功能迅速恢复。年龄较大和通气时间较长的变量减少，而 FSS-ICU 较高则增加了恢复独立坐位到站立位功能的机会。
