Chang Zengyi
Center for Protein Science, State Key Laboratory of Protein and Plant Gene Studies, School of Life Sciences, Center for History and Philosophy of Science, Peking University, Beijing, China.
IUBMB Life. 2016 Nov;68(11):904-907. doi: 10.1002/iub.1561. Epub 2016 Sep 26.
The DegP (or HtrA) is a highly conserved family of proteins functioning in all living organisms. It was initially identified as a protease functioning in the periplasmic space of the Gram-negative bacterial cells. It was later reported to also exhibit chaperone activity and thus has been designated as a bifunctional protein. However, recent studies demonstrated that in living cells it more likely functions only as a protease with hardly detectable chaperone activities. In this review, I will summarize the evidences clarifying that DegP more likely only functions as a protease rather than as a chaperone in cells. © 2016 IUBMB Life, 68(11):904-907, 2016.
DegP（或HtrA）是一类在所有生物中都有功能的高度保守的蛋白质家族。它最初被鉴定为一种在革兰氏阴性细菌细胞周质空间中发挥作用的蛋白酶。后来有报道称它也具有伴侣活性，因此被指定为一种双功能蛋白。然而，最近的研究表明，在活细胞中它更可能仅作为一种蛋白酶发挥作用，几乎检测不到伴侣活性。在这篇综述中，我将总结一些证据，这些证据表明DegP在细胞中更可能仅作为一种蛋白酶发挥作用，而不是作为一种伴侣蛋白。© 2016国际生物化学与分子生物学联盟生命科学部，68(11):904 - 907，2016年。
