氟桂利嗪对短暂性脑缺血所致压力反射衰减的影响。

Effect of flunarizine on the attenuation of baroreflex by transient cerebral ischemia.

作者信息

Kurihara J, Oda N, Kato H

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.

出版信息

Eur J Pharmacol. 1989 Jun 8;165(1):147-50. doi: 10.1016/0014-2999(89)90781-4.

DOI:10.1016/0014-2999(89)90781-4

PMID:2767131

Abstract

Baroreflex sensitivity assessed by phenylephrine-induced reflex bradycardia was markedly decreased by 5- an 10-min global cerebral ischemia in anesthetized dogs. Flunarizine, 0.1 and 1 mg/kg i.v., administered 5 min prior to 5-min ischemia, completely inhibited the decrease in baroreflex sensitivity while such a protective effect of the latter dose was incomplete against 10-min ischemia. In contrast, papaverine, 0.5 mg/kg per min i.v., infused for 5 min prior to 5-min ischemia, failed to protect the decrease in baroreflex sensitivity. Flunarizine may possess a certain direct cerebroprotective effect in addition to its cerebrocirculatory effect.

摘要

在麻醉犬中，通过去氧肾上腺素诱发的反射性心动过缓评估的压力感受性反射敏感性，在经历5分钟和10分钟的全脑缺血后显著降低。在5分钟缺血前5分钟静脉注射0.1和1mg/kg的氟桂利嗪，可完全抑制压力感受性反射敏感性的降低，而后者剂量对10分钟缺血的这种保护作用不完全。相比之下，在5分钟缺血前5分钟以每分钟0.5mg/kg的速度静脉输注罂粟碱，未能保护压力感受性反射敏感性的降低。除了对脑循环的作用外，氟桂利嗪可能还具有一定的直接脑保护作用。