Licznerska Barbara, Baer-Dubowska Wanda
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznan, Poland.
Adv Exp Med Biol. 2016;928:131-154. doi: 10.1007/978-3-319-41334-1_6.
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells. Although most of the current data support the role of I3C and DIM in prevention of hormone-dependent cancers, it seems that their application in prevention of the other cancer as well as cardiovascular disease, obesity, and diabetes reduction is also possible. This chapter summarizes the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in prevention of chronic diseases.
吲哚 - 3 - 甲醇（I3C）是十字花科蔬菜中的一种常见植物化学物质，其缩合产物3,3'-二吲哚基甲烷（DIM）在细胞和分子水平上具有多种生物活性，这有助于它们具有公认的化学预防潜力。起初，这些化合物被归类为能增加药物代谢酶活性的阻断剂。现在人们普遍认为，I3C和DIM会影响多种信号通路以及控制癌细胞中失调的细胞分裂、细胞凋亡或血管生成的靶分子。尽管目前的大多数数据支持I3C和DIM在预防激素依赖性癌症中的作用，但它们似乎也有可能用于预防其他癌症以及心血管疾病、肥胖症和降低糖尿病风险。本章总结了目前关于I3C和DIM活性的实验数据以及表明它们在预防慢性病中作用的临床研究结果。
