Deke John, Chiang Hanley
1 Mathematica Policy Research, Princeton, NJ, USA.
Eval Rev. 2017 Apr;41(2):130-154. doi: 10.1177/0193841X16670047. Epub 2016 Sep 26.
To limit the influence of attrition bias in assessments of intervention effectiveness, several federal evidence reviews have established a standard for acceptable levels of sample attrition in randomized controlled trials. These evidence reviews include the What Works Clearinghouse (WWC), the Home Visiting Evidence of Effectiveness Review, and the Teen Pregnancy Prevention Evidence Review. We believe the WWC attrition standard may constitute the first use of model-based, empirically supported bounds on attrition bias in the context of a federally sponsored systematic evidence review. Meeting the WWC attrition standard (or one of the attrition standards based on the WWC standard) is now an important consideration for researchers conducting studies that could potentially be reviewed by the WWC (or other evidence reviews).
The purpose of this article is to explain the WWC attrition model, how that model is used to establish attrition bounds, and to assess the sensitivity of attrition bounds to key parameter values.
Results are based on equations derived in the article and values generated by applying those equations to a range of parameter values.
The authors find that the attrition boundaries are more sensitive to the maximum level of bias that an evidence review is willing to tolerate than to other parameters in the attrition model.
The authors conclude that the most productive refinements to existing attrition standards may be with respect to the definition of "maximum tolerable bias."
为了限制样本损耗偏差对干预效果评估的影响,多项联邦证据审查为随机对照试验中可接受的样本损耗水平制定了标准。这些证据审查包括有效证据信息中心(WWC)、家访有效性证据审查和青少年怀孕预防证据审查。我们认为,在联邦政府资助的系统证据审查背景下,WWC损耗标准可能是首次使用基于模型且有实证支持的损耗偏差界限。对于开展可能会被WWC(或其他证据审查)审查的研究的研究者来说,满足WWC损耗标准(或基于WWC标准的损耗标准之一)现在是一个重要考量因素。
本文旨在解释WWC损耗模型、该模型如何用于确定损耗界限,以及评估损耗界限对关键参数值的敏感性。
结果基于本文推导的公式以及将这些公式应用于一系列参数值所产生的值。
作者发现,损耗界限对证据审查愿意容忍的最大偏差水平比对损耗模型中的其他参数更为敏感。
作者得出结论,对现有损耗标准最有效的改进可能在于“最大可容忍偏差”的定义。