Ziembicki Stephanie, Zhu Jie, Tse Elizabeth, Martin Lisa J, Minkin Salomon, Boyd Norman F
Campbell Family Institute for Breast Cancer Research, Princess Margaret Comprehensive Cancer Centre, Toronto, Ontario, Canada.
Cancer Epidemiol Biomarkers Prev. 2017 Feb;26(2):170-178. doi: 10.1158/1055-9965.EPI-16-0522. Epub 2016 Sep 26.
Percent breast density (PBD) is a strong risk factor for breast cancer that is influenced by several other risk factors for the disease. Alcohol consumption is associated with an increased risk of breast cancer with an uncertain association with PBD. We have carried out a systematic review and meta-analysis to examine the association of alcohol consumption with PBD.
We searched nine databases to identify all relevant studies on the association between alcohol intake and breast density. Two independent investigators evaluated and selected 20 studies that were included in our analyses. We divided the studies into three groups according to the methods used to measure and analyze the association of breast density with alcohol consumption.
Meta-analysis of the 11 studies that used quantitative methods to measure and analyze PBD as a continuous variable found a statistically significant difference in PBD when comparing the highest with the lowest alcohol level [β = 0.84; 95% confidence interval (CI), 0.12-1.56]. Three studies that used quantitative methods to measure PBD and categories of PBD for analysis had a summary OR = 1.81 (95% CI, 1.07-3.04). Five studies that used categories to classify PBD and analyze their association with alcohol intake had a summary OR = 1.78 (95% CI, 0.90-3.51).
These results suggest that there is a positive association between alcohol intake and PBD.
Alcohol may increase the risk of breast cancer associated with PBD. Cancer Epidemiol Biomarkers Prev; 26(2); 170-8. ©2016 AACR.
乳腺密度百分比（PBD）是乳腺癌的一个强风险因素，它还受该疾病的其他几个风险因素影响。饮酒与乳腺癌风险增加相关，与PBD的关联尚不确定。我们进行了一项系统评价和荟萃分析，以研究饮酒与PBD之间的关联。
我们检索了九个数据库，以识别所有关于酒精摄入量与乳腺密度之间关联的相关研究。两名独立研究者评估并筛选出20项纳入我们分析的研究。我们根据用于测量和分析乳腺密度与饮酒之间关联的方法，将这些研究分为三组。
对11项使用定量方法将PBD作为连续变量进行测量和分析的研究进行荟萃分析发现，比较最高与最低酒精水平时，PBD存在统计学显著差异[β = 0.84；95%置信区间（CI），0.12 - 1.56]。三项使用定量方法测量PBD并将PBD类别用于分析的研究，汇总OR = 1.81（95% CI，1.07 - 3.04）。五项使用类别对PBD进行分类并分析其与酒精摄入量关联的研究，汇总OR = 1.78（95% CI，0.90 - 3.51）。
这些结果表明，酒精摄入量与PBD之间存在正相关。
酒精可能会增加与PBD相关的乳腺癌风险。《癌症流行病学、生物标志物与预防》；26(2)；170 - 178。©2016美国癌症研究协会。
