Wei Jia, Wu Nan-Die, Liu Bao-Rui
Jia Wei, Nan-Die Wu, Bao-Rui Liu, Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China.
World J Gastroenterol. 2016 Sep 7;22(33):7478-85. doi: 10.3748/wjg.v22.i33.7478.
Peritoneal carcinomatosis appears to be the most common pattern of metastasis or recurrence and is associated with poor prognosis in gastric cancer patients. Many efforts have been made to improve the survival in patients with peritoneal metastasis. Hyperthermic intraperitoneal chemotherapy remains a widely accepted strategy in the treatment of peritoneal dissemination. Several phase II-III studies confirmed that the combined cytoreducitve surgery and hyperthermic intraperitoneal chemotherapy resulted in longer survival in patients with peritoneal carcinomatosis. In addition, proper selection and effective regional treatment in patients with high risk of peritoneal recurrence after resection will further improve prognosis in local advanced gastric cancer patients.
腹膜癌转移似乎是最常见的转移或复发模式，并且与胃癌患者的预后不良相关。人们已经做出了许多努力来提高腹膜转移患者的生存率。腹腔热灌注化疗仍然是治疗腹膜播散的一种广泛接受的策略。几项II-III期研究证实，细胞减灭术联合腹腔热灌注化疗可使腹膜癌转移患者的生存期延长。此外，对切除术后腹膜复发高危患者进行适当的选择和有效的局部治疗将进一步改善局部进展期胃癌患者的预后。
