Thyagarajan Braghadheeswar, Kumar Monisha Priyadarshini, Sikachi Rutuja R, Agrawal Abhinav
Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Madras Medical College, Chennai, India.
Intractable Rare Dis Res. 2016 Aug;5(3):177-84. doi: 10.5582/irdr.2016.01049.
Heart failure is one of the leading causes of death in developed nations. End stage heart failure often requires cardiac transplantation for survival. The left ventricular assist device (LVAD) has been one of the biggest evolvements in heart failure management often serving as bridge to transplant or destination therapy in advanced heart failure. Like any other medical device, LVAD is associated with complications with infections being reported in many patients. Endocarditis developing secondary to the placement of LVAD is not a frequent, serious and difficult to treat condition with high morbidity and mortality. Currently, there are few retrospective studies and case reports reporting the same. In our review, we found the most common cause of endocarditis in LVAD was due to bacteria. Both bacterial and fungal endocarditis were associated with high morbidity and mortality. In this review we will be discussing the risk factors, organisms involved, diagnostic tests, management strategies, complications, and outcomes in patients who developed endocarditis secondary to LVAD placement.
心力衰竭是发达国家主要的死亡原因之一。终末期心力衰竭常常需要进行心脏移植才能存活。左心室辅助装置（LVAD）一直是心力衰竭治疗领域最大的进展之一，常用于晚期心力衰竭患者的移植过渡或终末治疗。与其他任何医疗设备一样，LVAD也会引发并发症，许多患者都报告出现了感染情况。LVAD植入后继发的心内膜炎并不常见，但病情严重且难以治疗，发病率和死亡率都很高。目前，关于这方面的回顾性研究和病例报告较少。在我们的综述中，我们发现LVAD相关性心内膜炎最常见的病因是细菌。细菌和真菌性心内膜炎均与高发病率和高死亡率相关。在本综述中，我们将讨论LVAD植入后继发心内膜炎患者的危险因素、相关病原体、诊断测试、管理策略、并发症及预后情况。
