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Linezolid surveillance results for the United States: LEADER surveillance program 2011.利奈唑胺监测结果：美国 LEADER 监测项目 2011 年报告
Antimicrob Agents Chemother. 2013 Feb;57(2):1077-81. doi: 10.1128/AAC.02112-12. Epub 2012 Dec 17.
2
Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis.可转移质粒介导的利奈唑胺耐药性由于 cfr 在粪肠球菌的人类临床分离株中。
Antimicrob Agents Chemother. 2012 Jul;56(7):3917-22. doi: 10.1128/AAC.00419-12. Epub 2012 Apr 9.
3
The oxazolidinones: past, present, and future.恶唑烷酮类：过去、现在和未来。
Ann N Y Acad Sci. 2011 Dec;1241:48-70. doi: 10.1111/j.1749-6632.2011.06330.x.
4
Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.大环内酯类抗生素在核糖体出口隧道中的：种属特异性结合与作用。
Ann N Y Acad Sci. 2011 Dec;1241:33-47. doi: 10.1111/j.1749-6632.2011.06315.x.
5
Resistance to linezolid caused by modifications at its binding site on the ribosome.核糖体结合部位修饰导致对利奈唑胺的耐药性。
Antimicrob Agents Chemother. 2012 Feb;56(2):603-12. doi: 10.1128/AAC.05702-11. Epub 2011 Dec 5.
6
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05.耐甲氧西林金黄色葡萄球菌 CM05 中 cfr 的遗传环境和稳定性。
Antimicrob Agents Chemother. 2012 Jan;56(1):332-40. doi: 10.1128/AAC.05420-11. Epub 2011 Oct 24.
7
Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.肺炎链球菌中利奈唑胺耐药的全基因组分析揭示了耐药和补偿性突变。
BMC Genomics. 2011 Oct 17;12:512. doi: 10.1186/1471-2164-12-512.
8
Antibiotics that target protein synthesis.针对蛋白质合成的抗生素。
Wiley Interdiscip Rev RNA. 2011 Mar-Apr;2(2):209-32. doi: 10.1002/wrna.60. Epub 2010 Nov 22.
9
Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy.评估意大利罗马引起血流感染的表皮葡萄球菌中利奈唑胺耐药机制。
J Antimicrob Chemother. 2010 Nov;65(11):2329-35. doi: 10.1093/jac/dkq331. Epub 2010 Sep 14.
10
Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.耻垢分枝杆菌核糖体肽基转移酶中心的单个23S rRNA突变通过干扰药物结合口袋赋予对伐地米星和其他抗生素的抗性。
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一株具有对几种 rRNA 靶向药物交叉耐药表型的血链球菌分离株。

Streptococcus sanguinis isolate displaying a phenotype with cross-resistance to several rRNA-targeting agents.

机构信息

JMI Laboratories, North Liberty, Iowa, USA.

出版信息

J Clin Microbiol. 2013 Aug;51(8):2728-31. doi: 10.1128/JCM.00757-13. Epub 2013 May 22.

DOI:10.1128/JCM.00757-13
PMID:23698536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3719607/
Abstract

This study describes a clinical case of a 71-year-old male with a history of ischemic cardiomyopathy after left ventricular assist device (LVAD) endocarditis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) and a rare linezolid-resistant Streptococcus sanguinis strain (MIC, 32 μg/ml). The patient received courses of several antimicrobial agents, including linezolid for 79 days. The S. sanguinis strain had mutations in the 23S rRNA (T2211C, T2406C, G2576T, C2610T) and an amino acid substitution (N56D) in L22 and exhibited cross-resistance to ribosome-targeting agents.

摘要

本研究描述了一例临床病例，一名 71 岁男性患有左心室辅助装置 (LVAD) 心内膜炎后缺血性心肌病，病因是耐甲氧西林表皮葡萄球菌 (MRSE) 和一种罕见的利奈唑胺耐药的血链球菌株 (MIC，32μg/ml)。该患者接受了多种抗菌药物治疗，包括利奈唑胺治疗 79 天。血链球菌株在 23S rRNA 中发生突变 (T2211C、T2406C、G2576T、C2610T) 和 L22 中的氨基酸取代 (N56D)，并表现出对核糖体靶向药物的交叉耐药性。