青年与成年非酒精性肝硬化患者的临床特征、病程、病毒标志物及随访——一项回顾性研究

Clinical features, course, viral markers and follow-up in young versus adult nonalcoholic cirrhotics--a retrospective study.

作者信息

Qureshi H, Zuberi S J, Lodi T Z, Alam E

机构信息

Pakistan Medical Research Council, Jinnah Postgraduate Medical Center, Karachi.

出版信息

Digestion. 1989;42(2):110-5. doi: 10.1159/000199834.

DOI:10.1159/000199834

PMID:2767341

Abstract

To determine the presenting features and prognosis of nonalcoholic cirrhosis, retrospective analysis was done in 145 cases. Of the total, 48 patients (33%) belonged to the young (less than or equal to 35 years), and 97 (67%) to the adult age group (greater than 35 years) with no predominance of either sex. The etiology of cirrhosis and the positivity of viral markers were similar in both groups. Adults had on presentation a higher frequency of anorexia while hematemesis was more frequent in the young group (p less than 0.001). During a mean follow-up (+/- SE) of 31.7 +/- 5.5 and 16.3 +/- 2.2 months in the young and adult group, respectively, 68 and 63% cases survived 5 years. Liver failure (53.8 and 44.4%) and variceal bleeding (23 and 11.1%) were the main causes of death in both groups, accounting for 27% mortality in each group.

摘要

为确定非酒精性肝硬化的临床表现特征及预后，对145例患者进行了回顾性分析。其中，48例患者（33%）为青年（年龄小于或等于35岁），97例（67%）为成年组（年龄大于35岁），且无性别优势。两组患者的肝硬化病因及病毒标志物阳性率相似。成年组患者出现厌食的频率较高，而青年组呕血更为常见（p<0.001）。青年组和成年组的平均随访时间（±标准误）分别为31.7±5.5个月和16.3±2.2个月，5年生存率分别为68%和63%。肝衰竭（53.8%和44.4%）和静脉曲张破裂出血（23%和11.1%）是两组患者的主要死亡原因，每组死亡率均为27%。