Chen Jian-Ling, Yang Jian-Ming, Huang Ya-Zhe, Li Ying
Department of Reproductive Medicine, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China.
Department of Obstetrics and Gynecology, Reproductive Medical Center, The Center Hospital of Nanyang, Nanyang 473009, China.
Int Immunopharmacol. 2016 Nov;40:347-350. doi: 10.1016/j.intimp.2016.09.018. Epub 2016 Sep 24.
This study aims to investigate the clinical curative effect of lymphocyte active immunotherapy (LAI) on unexplained recurrent spontaneous abortion (RSA).
A total of 749 RSA patients who received medical service in our hospital from October 2009 to June 2013 were enrolled into this study. These patients were randomly divided into two groups: LAI group (treatment group) and routine progesterone for maintenance tocolysis group (control group). A comparative analysis on the pregnancy outcomes in these two groups was conducted.
Abortion rate was significantly lower in the LAI group than in the control group (P<0.05). Furthermore, pregnancy success rates were 89.7% and 32.2% in patients who received LAI and routine progesterone for maintenance tocolysis, respectively, and the difference was statistically significant (P<0.05).
Our analysis suggested that LAI can treat RSA effectively and has an excellent clinical effect. Furthermore, the detection of blocking antibodies showed a positive prediction on pregnancy outcome.
本研究旨在探讨淋巴细胞主动免疫疗法（LAI）对不明原因复发性自然流产（RSA）的临床疗效。
选取2009年10月至2013年6月在我院就诊的749例RSA患者纳入本研究。将这些患者随机分为两组：LAI组（治疗组）和常规黄体酮维持保胎组（对照组）。对两组的妊娠结局进行比较分析。
LAI组的流产率显著低于对照组（P<0.05）。此外，接受LAI和常规黄体酮维持保胎的患者妊娠成功率分别为89.7%和32.2%，差异有统计学意义（P<0.05）。
我们的分析表明，LAI可有效治疗RSA，具有良好的临床效果。此外，封闭抗体检测对妊娠结局有阳性预测作用。
