Research Experimental Center, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, China.
Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital) Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, China.
Immun Inflamm Dis. 2021 Dec;9(4):1272-1278. doi: 10.1002/iid3.474. Epub 2021 Jun 8.
Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial. This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may influence the outcome of LIT.
This study included a total of 704 URSA patients, of which 444 patients accepted LIT treatment. URSA patients that did not accept LIT served as control group. Clinical characteristics were collected and analyzed between LIT and control group. The blocking antibody was tested before and after LIT. The outcome of LIT treatment was recorded. Logistic regression analysis was applied to evaluate the independent predictors of LIT success.
After LIT treatment, 77.9% (346/444) of USRA patients turned to BA positive, and the conversion rate elevated with increased LIT (p < .001). LIT significantly improved the pregnancy rate and live birth rate in USRA patients (65.3% vs. 29.6%, p < .001; 80.3% vs. 50.6%, p < .001). Multivariate regression analysis suggested that younger maternal age and positive BA were independent predictors of LIT success.
LIT effectively induced the production of BA, and improved pregnancy rate and live birth rate in URSA patients. Our findings supported LIT as a beneficial treatment for URSA.
淋巴细胞免疫疗法（LIT）被认为是治疗不明原因复发性自然流产（URSA）的一种可行方法，但它的效果仍存在争议。本研究旨在探讨 LIT 对 URSA 患者的临床疗效，并阐明可能影响 LIT 结果的因素。
本研究共纳入 704 例 URSA 患者，其中 444 例接受了 LIT 治疗。未接受 LIT 治疗的 URSA 患者作为对照组。收集并分析 LIT 组和对照组之间的临床特征。在 LIT 前后检测阻断抗体。记录 LIT 治疗的结果。应用逻辑回归分析评估 LIT 成功的独立预测因素。
在 LIT 治疗后，77.9%（346/444）的 URSA 患者转为 BA 阳性，且随着 LIT 的增加，转化率升高（p < .001）。LIT 显著提高了 URSA 患者的妊娠率和活产率（65.3%比 29.6%，p < .001；80.3%比 50.6%，p < .001）。多变量回归分析表明，母亲年龄较小和 BA 阳性是 LIT 成功的独立预测因素。
LIT 能有效诱导 BA 的产生，提高 URSA 患者的妊娠率和活产率。我们的研究结果支持 LIT 作为治疗 URSA 的有益方法。
