Sugiyama Yuko, Sasaki Hiroshi, Komatsu Kyoko, Yabushita Ryuji, Oda Mizue, Yanoh Kenji, Ueda Masatsugu, Itamochi Hiroaki, Okugawa Kaoru, Fujita Hiromasa, Tase Toru, Nakatani Eiji, Moriya Takuya
The Japanese Society of Clinical Cytology Study Group on the Use of Automated Screening Systems for Quality Control Purposes regarding Cervical Cytology, Cancer Institute Hospital, Tokyo, Japan.
Acta Cytol. 2016;60(5):451-457. doi: 10.1159/000449499. Epub 2016 Sep 28.
To evaluate the efficacy of the automated screening system FocalPoint for cervical cytology quality control (QC) rescreening. False-negative rates (FNRs) were evaluated by a multi-institutional retrospective study.
Cervical cytology slides that had already been reported as negative for intraepithelial lesion or malignancy (NILM) were chosen arbitrarily for FocalPoint rescreening. Slides stratified into the highest 15% probability of being abnormal were rescreened by a cytotechnologist. The slides that were abnormal were reevaluated by a cytopathologist to be false negatives.
Rescreening of 12,000 slides, i.e. 9,000 conventional slides and 3,000 liquid-based cytology (LBC) slides, was performed; 9,826 (7,393 conventional and 2,433 LBC) were satisfactory for FocalPoint (2,174 were determined unsatisfactory) and those within the highest 15% of probability (1,496, i.e. 1,123 conventional and 373 LBC) were rescreened. As a result, 117 (96 conventional and 21 LBC) were determined as abnormal (other than NILM) and the FNR was 1.19%. Among these 117 slides, 40 (35 conventional and 5 LBC) were determined as high-grade squamous intraepithelial lesion and greater (HSIL+).
Of 117 (1.19%) abnormal slides detected, 40 (0.41%) were determined to be HSIL+. This result suggests that FocalPoint is effective for QC rescreening of cervical cytology.
评估自动化筛查系统FocalPoint用于宫颈细胞学质量控制（QC）复查的效果。通过多机构回顾性研究评估假阴性率（FNR）。
任意选择已报告为上皮内病变或恶性肿瘤阴性（NILM）的宫颈细胞学玻片进行FocalPoint复查。将概率最高的15%可能异常的玻片由细胞技术人员进行复查。对异常的玻片由细胞病理学家重新评估以确定为假阴性。
对12,000张玻片进行了复查，即9,000张传统玻片和3,000张液基细胞学（LBC）玻片；9,826张（7,393张传统玻片和2,433张LBC玻片）FocalPoint复查结果满意（2,174张被判定为不满意），对概率最高的15%的玻片（1,496张，即1,123张传统玻片和373张LBC玻片）进行了复查。结果，117张（96张传统玻片和21张LBC玻片）被判定为异常（非NILM），FNR为1.19%。在这117张玻片中，40张（35张传统玻片和5张LBC玻片）被判定为高级别鳞状上皮内病变及更高级别（HSIL+）。
在检测出的117张（1.19%）异常玻片中，40张（0.41%）被判定为HSIL+。这一结果表明FocalPoint在宫颈细胞学QC复查中是有效的。
