Duroux P, Bauerfeind P, Emde C, Koelz H R, Blum A L
Centre Hospitalier Universitaire Vaudois, Gastroentérologie, Lausanne, Switzerland.
Gut. 1989 Aug;30(8):1063-7. doi: 10.1136/gut.30.8.1063.
This study examines whether eating food at different times has differential effects on intragastric pH. Experiments were done in 23 healthy volunteers (12 men). Intragastric acidity was monitored by ambulatory 22 hour pH-metry. Composition of meals was standardised: breakfast and lunch at 7 am and 12 noon respectively, and dinner at 6 or 9 pm, in random order. The time of going to bed and getting up was also standardised. With early dinner nocturnal pH was higher, than with late dinner (pH median: 1.67 and 1.39, p less than 0.001). During the remaining time periods, pH values were similar. Thus early dinner may be helpful in conditions where low intragastric acidity is desirable.
本研究探讨在不同时间进食是否会对胃内pH值产生不同影响。对23名健康志愿者（12名男性）进行了实验。通过动态22小时pH测量法监测胃内酸度。膳食组成标准化：早餐和午餐分别在上午7点和中午12点，晚餐在下午6点或9点，顺序随机。上床睡觉和起床时间也标准化。晚餐较早时夜间pH值高于晚餐较晚时（pH中位数：1.67和1.39，p<0.001）。在其余时间段，pH值相似。因此，在需要低胃内酸度的情况下，晚餐较早可能有益。
