通过原位杂交将尿苷单磷酸合酶基因定位到人类染色体3q13区域。
Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization.
作者信息
Qumsiyeh M B, Valentine M B, Suttle D P
机构信息
Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis 38101.
出版信息
Genomics. 1989 Jul;5(1):160-2. doi: 10.1016/0888-7543(89)90103-1.
PMID:2767686
Abstract
The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization.
摘要
双功能酶尿苷单磷酸（UMP）合酶催化从头嘧啶生物合成的最后两步。该酶活性的遗传缺陷会导致遗传性人类疾病乳清酸尿症。我们使用人cDNA探针，通过原位杂交技术将UMP合酶基因定位到人类染色体区域3q13。
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