Qumsiyeh M B
Duke University Medical Center, Cytogenetics Laboratory, Durham, NC 27710, USA.
Chromosome Res. 1995 Dec;3(8):455-65. doi: 10.1007/BF00713959.
A synthesis of numerous published data and my own observations reveal that chromatin structure in interphase is functional, dynamic and complex. I hypothesize that: (1) chromosome regions organize nuclear structures and thus their own environment (address themselves in sites and condensation patterns most appropriate for their functional state in the particular cell); (2) chromosome rearrangement could alter nuclear architecture and thus function; and (3) these ideas can explain the contribution of chromosome rearrangements, even in a balanced form, to human pathologic conditions.
大量已发表数据与我自己的观察结果综合表明，间期染色质结构具有功能性、动态性且复杂。我推测：（1）染色体区域组织核结构，进而组织其自身所处环境（以最适合其在特定细胞中功能状态的位点和凝聚模式定位自身）；（2）染色体重排可改变核结构进而影响其功能；（3）这些观点能够解释染色体重排，即便以平衡形式，对人类病理状况的影响。
