Dy-Ledesma Janelyn L, Khoury Joseph D, Agbay Rose Lou Marie C, Garcia Mar, Miranda Roberto N, Medeiros L Jeffrey
*Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX †Department of Pathology, Hospital del Mar, Barcelona, Spain.
Adv Anat Pathol. 2016 Nov;23(6):343-355. doi: 10.1097/PAP.0000000000000127.
The starry sky pattern is a distinctive histologic feature wherein a rapidly proliferating hematolymphoid neoplasm contains scattered histiocytes with abundant pale cytoplasm in a background of monomorphic neoplastic cells. The cytoplasm of these histiocytes typically contains cellular remnants, also known as tingible bodies, incorporated through active phagocytosis. Although common and widely recognized, relatively little is known about the pathophysiological underpinnings of the starry sky pattern. Its resemblance to a similar pattern seen in the germinal centers of secondary follicles suggests a possible starting point for understanding the molecular basis of the starry sky pattern and potential routes for its exploitation for therapeutic purposes. In this review, we discuss the historical, pathophysiological, and clinical implications of the starry sky pattern.
星空样图案是一种独特的组织学特征，其中快速增殖的血液淋巴肿瘤在单形性肿瘤细胞背景中含有散在的组织细胞，这些组织细胞具有丰富的淡染细胞质。这些组织细胞的细胞质通常含有通过活跃吞噬作用摄取的细胞残余物，也称为可染小体。尽管星空样图案常见且广为人知，但对其病理生理基础的了解相对较少。它与在次级滤泡生发中心看到的类似图案相似，这提示了一个理解星空样图案分子基础的可能起点以及将其用于治疗目的的潜在途径。在本综述中，我们讨论了星空样图案的历史、病理生理及临床意义。
