Chitnis M P, Kamath N S, Advani S H
Indian J Med Res. 1989 Jun;90:197-202.
The effect of reserpine was studied alone and in combination with anticancer drugs on human chronic myeloid leukaemia (CML) cells. To study the effect of reserpine on anthracycline antibiotic adriamycin and anthracenedione mitoxantrone the extent of 3H-thymidine incorporation into the DNA was taken as the measure of cytotoxicity. The results indicate that reserpine enhances the cytotoxicity of mitoxantrone and adriamycin in mildly toxic concentrations (1 and 10 micrograms respectively), in CML cells. The mechanism of enhancement in drug sensitivity by reserpine in CML cells is due to enhanced intracellular accumulation of drug.
研究了利血平单独使用以及与抗癌药物联合使用对人慢性粒细胞白血病（CML）细胞的作用。为了研究利血平对蒽环类抗生素阿霉素和蒽二酮米托蒽醌的作用，将3H-胸腺嘧啶核苷掺入DNA的程度作为细胞毒性的衡量指标。结果表明，在CML细胞中，利血平在轻度毒性浓度（分别为1和10微克）下可增强米托蒽醌和阿霉素的细胞毒性。利血平增强CML细胞对药物敏感性的机制是由于药物在细胞内的积累增加。
