Chawla R, Arora M K, Saksena R, Gode G R
Indian J Med Res. 1989 Jun;90:220-3.
With a view to assess the efficacy of intrathecal pentazocine for post-operative pain relief, 60 patients randomly divided into 6 equal groups were administered graded doses (0, 1, 2, 3, 4 and 5 mg respectively) of pentazocine lactate, intrathecally along with 1 per cent bupivacaine. The duration of analgesia was found to be dose related till 3 mg. Higher doses did not increase the duration of analgesia nor were any untoward effects observed. It is concluded that intrathecal pentazocine is safe and effective for post-operative pain relief and 3 mg is the minimum effective dose without side effect.
为评估鞘内注射喷他佐辛用于术后镇痛的疗效，将60例患者随机分为6组，每组人数相等，分别鞘内注射梯度剂量（分别为0、1、2、3、4和5毫克）的乳酸喷他佐辛，同时注射1%布比卡因。结果发现，镇痛持续时间与剂量相关，直至3毫克。更高剂量并未增加镇痛持续时间，也未观察到任何不良反应。得出的结论是，鞘内注射喷他佐辛用于术后镇痛安全有效，3毫克是无副作用的最小有效剂量。
