Riccelli Roberta, Indovina Iole, Staab Jeffrey P, Nigro Salvatore, Augimeri Antonio, Lacquaniti Francesco, Passamonti Luca
Department of Medical and Surgical Sciences, University "Magna Graecia,", Catanzaro, Italy.
Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, 00179, Italy.
Hum Brain Mapp. 2017 Feb;38(2):715-726. doi: 10.1002/hbm.23411. Epub 2016 Sep 28.
Different lines of research suggest that anxiety-related personality traits may influence the visual and vestibular control of balance, although the brain mechanisms underlying this effect remain unclear. To our knowledge, this is the first functional magnetic resonance imaging (fMRI) study that investigates how individual differences in neuroticism and introversion, two key personality traits linked to anxiety, modulate brain regional responses and functional connectivity patterns during a fMRI task simulating self-motion. Twenty-four healthy individuals with variable levels of neuroticism and introversion underwent fMRI while performing a virtual reality rollercoaster task that included two main types of trials: (1) trials simulating downward or upward self-motion (vertical motion), and (2) trials simulating self-motion in horizontal planes (horizontal motion). Regional brain activity and functional connectivity patterns when comparing vertical versus horizontal motion trials were correlated with personality traits of the Five Factor Model (i.e., neuroticism, extraversion-introversion, openness, agreeableness, and conscientiousness). When comparing vertical to horizontal motion trials, we found a positive correlation between neuroticism scores and regional activity in the left parieto-insular vestibular cortex (PIVC). For the same contrast, increased functional connectivity between the left PIVC and right amygdala was also detected as a function of higher neuroticism scores. Together, these findings provide new evidence that individual differences in personality traits linked to anxiety are significantly associated with changes in the activity and functional connectivity patterns within visuo-vestibular and anxiety-related systems during simulated vertical self-motion. Hum Brain Mapp 38:715-726, 2017. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
不同的研究方向表明，与焦虑相关的人格特质可能会影响视觉和前庭对平衡的控制，尽管这种影响背后的大脑机制尚不清楚。据我们所知，这是第一项功能磁共振成像（fMRI）研究，该研究调查了神经质和内向性这两种与焦虑相关的关键人格特质的个体差异，如何在模拟自我运动的fMRI任务中调节大脑区域反应和功能连接模式。24名具有不同神经质和内向水平的健康个体在进行虚拟现实过山车任务时接受了fMRI检查，该任务包括两种主要类型的试验：（1）模拟向下或向上自我运动（垂直运动）的试验，以及（2）模拟在水平平面上自我运动（水平运动）的试验。比较垂直运动试验和水平运动试验时的区域脑活动和功能连接模式，与五因素模型的人格特质（即神经质、外向性-内向性、开放性、宜人性和尽责性）相关。在比较垂直运动试验和水平运动试验时，我们发现神经质得分与左侧顶叶岛叶前庭皮质（PIVC）的区域活动之间存在正相关。对于相同的对比，还检测到随着神经质得分的升高，左侧PIVC与右侧杏仁核之间的功能连接增加。总之这些发现提供了新的证据，表明与焦虑相关的人格特质的个体差异，与模拟垂直自我运动期间视觉前庭和焦虑相关系统内的活动和功能连接模式的变化显著相关。《人类大脑图谱》38:715 - 726，2017年。© 2016作者。《人类大脑图谱》由威利期刊公司出版。
