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国际疾病分类第11版中提出的复杂性创伤后应激障碍:儿童和青少年新疾病的验证及其对创伤聚焦认知行为疗法的反应

Complex PTSD as proposed for ICD-11: validation of a new disorder in children and adolescents and their response to Trauma-Focused Cognitive Behavioral Therapy.

作者信息

Sachser Cedric, Keller Ferdinand, Goldbeck Lutz

机构信息

Clinic for Child and Adolescent Psychiatry/Psychotherapy, University of Ulm, Ulm, Germany.

出版信息

J Child Psychol Psychiatry. 2017 Feb;58(2):160-168. doi: 10.1111/jcpp.12640. Epub 2016 Sep 28.

DOI:10.1111/jcpp.12640
PMID:27677771
Abstract

BACKGROUND

To evaluate whether the symptoms of children and adolescents with clinically significant posttraumatic stress symptoms (PTSS) form classes consistent with the diagnostic criteria of complex PTSD (CPTSD) as proposed for the ICD-11, and to relate the emerging classes with treatment outcome of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT).

METHODS

Latent classes analysis (LCA) was used to explore the symptom profiles of the clinical baseline assessment of N = 155 children and adolescents participating in a randomized controlled trial of TF-CBT. The treatment outcomes of patients with posttraumatic stress disorder (PTSD) and of patients with CPTSD were compared by a t-test for depended samples and a repeated-measures ANOVA.

RESULTS

The LCA revealed two distinct classes: a PTSD class characterized by elevated core symptoms of PTSD (n = 62) and low symptoms of disturbances in self-organization versus a complex PTSD class with elevated PTSD core symptoms and elevated symptoms of disturbances in self-organization (n = 93). The Group × Time interaction regarding posttraumatic stress symptoms was not significant. Pre-post effect sizes regarding posttraumatic stress symptoms were large for both groups (PTSD: d = 2.81; CPTSD: d = 1.37). For disturbances in self-organization in the CPTSD class, we found medium to large effect sizes (d = 0.40-1.16) after treatment with TF-CBT.

CONCLUSIONS

The results provide empirical evidence of the ICD-11 CPTSD and PTSD distinction in a clinical sample of children and adolescents. In terms of relative improvement from their respective baseline posttraumatic stress symptoms, patients with PTSD and CPTSD responded equally to TF-CBT; however, those with CPTSD ended treatment with clinically and statistically greater symptoms than those with PTSD.

摘要

背景

评估患有具有临床意义的创伤后应激症状(PTSS)的儿童和青少年的症状是否形成与国际疾病分类第11版(ICD - 11)中提出的复杂创伤后应激障碍(CPTSD)诊断标准一致的类别,并将新出现的类别与创伤聚焦认知行为疗法(TF - CBT)的治疗结果相关联。

方法

潜在类别分析(LCA)用于探索参与TF - CBT随机对照试验的N = 155名儿童和青少年临床基线评估的症状概况。通过配对样本t检验和重复测量方差分析比较创伤后应激障碍(PTSD)患者和CPTSD患者的治疗结果。

结果

LCA揭示了两个不同的类别:一个PTSD类别,其特征是PTSD的核心症状升高(n = 62)且自我组织障碍症状较低;另一个是复杂PTSD类别,其PTSD核心症状升高且自我组织障碍症状升高(n = 93)。关于创伤后应激症状的组×时间交互作用不显著。两组创伤后应激症状的前后效应量都很大(PTSD:d = 2.81;CPTSD:d = 1.37)。对于CPTSD类别中的自我组织障碍,我们发现TF - CBT治疗后效应量为中等至大(d = 0.40 - 1.16)。

结论

结果为ICD - 11中CPTSD和PTSD在儿童和青少年临床样本中的区分提供了实证证据。就各自基线创伤后应激症状的相对改善而言,PTSD患者和CPTSD患者对TF - CBT的反应相同;然而,CPTSD患者结束治疗时的临床症状和统计学症状比PTSD患者更严重。

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