神经内分泌学：雌激素治疗影响大脑结构而非功能。
Neuroendocrinology: Oestrogen therapy affects brain structure but not function.
机构信息
University of Arizona Center for Innovation in Brain Science, College of Medicine, 1501 North Campbell Avenue, P.O. BOX 245126, Tucson, Arizona 85724-5126, USA.
出版信息
Nat Rev Neurol. 2016 Sep 28;12(10):561-2. doi: 10.1038/nrneurol.2016.147.
Abstract
According to new research, oestrogen therapy in postmenopausal women is associated with ventricular enlargement and increased white matter hyperintensities in the brain, but not with cognitive decline. This disconnect between structural and functional effects suggests that brain-derived lipids can be harnessed to meet the bioenergetic demand imposed by normal cognition.
摘要
根据新的研究，绝经后女性的雌激素治疗与心室扩大和大脑白质高信号增加有关，但与认知能力下降无关。这种结构和功能影响之间的脱节表明，可以利用脑源性脂质来满足正常认知所带来的生物能量需求。
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2
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Neurobiol Aging. 2016 Apr;40:155-163. doi: 10.1016/j.neurobiolaging.2016.01.011. Epub 2016 Jan 29.
3
White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease.脑老化女性白质脂质作为生酮供能物质：对阿尔茨海默病的影响。
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4
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6
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8
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9
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