In Vitro Fertilization Center, Konak Hastanesi, İzmit, Kocaeli, Turkey.
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada; OriginElle Reporductive and Womens' Health Center, Montreal, Quebec, Canada.
Fertil Steril. 2016 Dec;106(7):1691-1695. doi: 10.1016/j.fertnstert.2016.08.026. Epub 2016 Sep 24.
To compare the clinical outcome of single-embryo transfer (SET) with double-embryo transfer (DET) in in vitro maturation (IVM) cycles performed in patients with polycystic ovary syndrome (PCOS), and to determine which factors predict those outcomes.
A retrospective analysis.
Private assisted reproduction center.
PATIENT(S): One hundred and fifty-nine women with PCOS.
INTERVENTION(S): In vitro maturation with elective SET or DET conducted between September 2007 and May 2014.
MAIN OUTCOME MEASURE(S): Live-birth rates.
RESULT(S): Single-embryo transfer was performed in 83 patients (52.2%), and DET was performed in 76 patients (47.7%). When compared with the patients who had DET, the patients who had SET were statistically significantly younger (32.4 ± 3.5 vs. 24.1 ± 4.2 years) and had a shorter infertility duration (9.2 ± 4.5 vs. 4.4 ± 2.1 years), fewer previous ART cycles (<2 prior attempts, 39.5% vs. 6%; ≥2 prior attempts, 60.5% vs. 0), fewer collected oocytes (15.1 ± 4.6 vs. 12.6 ± 3.8), fewer metaphase II oocytes (9.0 ± 4.1 vs. 5.7 ± 2.9), fewer fertilized oocytes (8.2 ± 3.7 vs. 3.6 ± 2.3), and a higher implantation rate (27% vs. 47%). The SET and DET groups had similar embryo quality and similar clinical pregnancy (44.6% vs. 44.7%) and live-birth rates (34.9% vs. 34.2%). Twin pregnancy rates were statistically significantly higher in the DET compared with the SET groups (9.2% vs. 2.4%).
CONCLUSION(S): In vitro maturation is a successful assisted reproduction technique that can be an alternative to conventional in vitro fertilization in women presenting with PCOS-related infertility. Our observations suggest that SET is a feasible option to prevent multiple pregnancies while maintaining the live-birth rate.
比较多囊卵巢综合征（PCOS）患者行体外成熟（IVM）周期中单胚胎移植（SET）和双胚胎移植（DET）的临床结局，并确定哪些因素可以预测这些结局。
回顾性分析。
私人辅助生殖中心。
PATIENT（S）：159 例 PCOS 患者。
INTERVENTION（S）：2007 年 9 月至 2014 年 5 月期间进行 IVM 中选择性 SET 或 DET。
MAIN OUTCOME MEASURE（S）：活产率。
83 例患者（52.2%）行 SET，76 例患者（47.7%）行 DET。与行 DET 的患者相比，行 SET 的患者年龄明显更小（32.4±3.5 岁比 24.1±4.2 岁），不孕时间更短（9.2±4.5 岁比 4.4±2.1 岁），ART 周期更少（<2 次尝试，39.5%比 6%；≥2 次尝试，60.5%比 0），获卵数更少（15.1±4.6 枚比 12.6±3.8 枚），MⅡ 卵数更少（9.0±4.1 枚比 5.7±2.9 枚），受精卵数更少（8.2±3.7 枚比 3.6±2.3 枚），着床率更高（27%比 47%）。SET 组和 DET 组胚胎质量相似，临床妊娠率（44.6%比 44.7%）和活产率（34.9%比 34.2%）相似。DET 组双胎妊娠率明显高于 SET 组（9.2%比 2.4%）。
IVM 是一种成功的辅助生殖技术，可作为 PCOS 相关不孕患者的常规体外受精的替代方法。我们的观察结果表明，SET 是一种可行的选择，可以在保持活产率的同时预防多胎妊娠。
