Martin R J, Drewry M, Jewell D, Harris R B, Young R, Patton J S
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Int J Obes. 1989;13(3):327-35.
Lean and obese Zucker rats were injected daily intraperitoneally with high doses (5-10 mg/kg) of human growth hormone (GH) for 3 weeks. In the obese rats after GH treatment, carcass lipid was decreased by 50 percent, and bone weight increased to levels of lean controls. During the last two weeks of GH treatment, food intake was increased in lean rats and not significantly affected in obese rats. Loss of body weight in obese animals was masked by water retention. Serum insulin concentrations were doubled in obese animals but unchanged in lean phenotypes after GH treatment. Hepatic fatty acid oxidation in obese animals was stimulated 5-fold by treatment, while hepatic lipid synthesis was stimulated 2-fold and adipose lipid synthesis was reduced 3-fold. These results suggest that growth hormone induces a partitioning of nutrients in obese rats which results in less lipid accumulation.
将瘦型和肥胖型 Zucker 大鼠每日腹腔注射高剂量（5 - 10 毫克/千克）的人生长激素（GH），持续 3 周。在接受 GH 治疗后的肥胖大鼠中，胴体脂质减少了 50%，骨重量增加到瘦型对照的水平。在 GH 治疗的最后两周，瘦型大鼠的食物摄入量增加，而肥胖大鼠的食物摄入量未受到显著影响。肥胖动物的体重减轻被水分潴留所掩盖。GH 治疗后，肥胖动物的血清胰岛素浓度翻倍，而瘦型表型的血清胰岛素浓度未发生变化。治疗使肥胖动物的肝脏脂肪酸氧化增加了 5 倍，同时肝脏脂质合成增加了 2 倍，脂肪脂质合成减少了 3 倍。这些结果表明，生长激素在肥胖大鼠中诱导了营养物质的重新分配，从而减少了脂质积累。
