Backon J, Kullok S
Mount Pleasant Hospital Addiction Studies Foundation, Lynn, MA.
Int J Neurosci. 1989 May;46(1-2):53-9. doi: 10.3109/00207458908991614.
The involuntary blink rate is a clinical monitor of dopaminergic activity. Since there is disagreement in the literature on the relative neurochemical hemispheric asymmetry or laterality of dopamine, we studied the effects of differential forced unilateral nostril breathing on blink rate. This technique has been demonstrated to induce selective contralateral hemispheric stimulation as measured by relative increases in the EEG amplitude as well as alternating lateralization of plasma catecholamines. We used the artifact of the two-channel electro-oculogram to measure the endogenous eyeblink in an N = 1 design with 11 reversals of left vs. right hemisphere activation. There was a significant increase in blink rate (p less than .01) with right hemisphere activation, and this suggests that dopamine may be lateralized to the right cerebral hemisphere.
非自主眨眼频率是多巴胺能活动的一种临床监测指标。由于文献中对于多巴胺在神经化学方面相对的半球不对称性或偏侧性存在分歧，我们研究了差异性强制单侧鼻孔呼吸对眨眼频率的影响。通过脑电图振幅的相对增加以及血浆儿茶酚胺的交替性偏侧化测量，已证明该技术可诱导选择性对侧半球刺激。我们采用两通道眼电图的伪迹，在N = 1的设计中测量内源性眨眼，左右半球激活有11次反转。右半球激活时眨眼频率显著增加（p小于0.01），这表明多巴胺可能偏侧于右侧大脑半球。
