Miyahira Andrea K, Roychowdhury Sameek, Goswami Sangeeta, Ippolito Joseph E, Priceman Saul J, Pritchard Colin C, Sfanos Karen S, Subudhi Sumit K, Simons Jonathan W, Pienta Kenneth J, Soule Howard R
Prostate Cancer Foundation, Santa Monica, California.
Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University, Columbus, Ohio.
Prostate. 2017 Feb;77(2):123-144. doi: 10.1002/pros.23260. Epub 2016 Sep 28.
The 2016 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer," was held from June 23 to June 26, 2016, in Coronado, California.
For the 4th year in a row, the Prostate Cancer Foundation (PCF) hosted the CHPCA Meeting, a think tank-structured scientific conference, which focuses on a specific topic of critical unmet need on the biology and treatment of advanced prostate cancer. The 2016 CHPCA Meeting was attended by 71 investigators from prostate cancer and other fields, who discussed the biology, study methodologies, treatment strategies, and critical unmet needs concerning metastatic prostate cancer, with the ultimate goal of advancing strategies to treat and eliminate this disease.
The major topics of discussion included: the molecular landscape and molecular heterogeneity of metastatic prostate cancer, the role of the metastatic microenvironment, optimizing immunotherapy in metastatic prostate cancer, learning from exceptional responders and non-responders, targeting DNA repair deficiency in advanced prostate cancer, developing and applying novel biomarkers and imaging techniques, and potential roles for the microbiome in prostate cancer.
This article reviews the topics presented and discussions held at the CHPCA Meeting, with a focus on the unknowns and next steps needed to advance our understanding of the biology and most effective treatment strategies for metastatic prostate cancer. Prostate 77:123-144, 2017. © 2016 Wiley Periodicals, Inc.
2016年科菲-霍尔登前列腺癌学会（CHPCA）会议“超越种子与土壤：理解与靶向转移性前列腺癌”于2016年6月23日至26日在加利福尼亚州科罗纳多举行。
前列腺癌基金会（PCF）连续第四年主办了CHPCA会议，这是一个采用智库结构的科学会议，聚焦于晚期前列腺癌生物学和治疗方面关键未满足需求的特定主题。2016年CHPCA会议有来自前列腺癌及其他领域的71名研究人员参加，他们讨论了转移性前列腺癌的生物学、研究方法、治疗策略以及关键未满足需求，最终目标是推进治疗和消除这种疾病的策略。
主要讨论主题包括：转移性前列腺癌的分子格局和分子异质性、转移微环境的作用、优化转移性前列腺癌的免疫治疗、从特殊应答者和无应答者中学习、靶向晚期前列腺癌中的DNA修复缺陷、开发和应用新型生物标志物及成像技术，以及微生物群在前列腺癌中的潜在作用。
本文回顾了CHPCA会议上提出的主题和进行的讨论，重点关注在推进我们对转移性前列腺癌生物学和最有效治疗策略理解方面的未知因素和后续步骤。《前列腺》77:123 - 144，2017年。© 2016威利期刊公司。
