Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.
Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Chem Rev. 2016 Oct 12;116(19):12536-12563. doi: 10.1021/acs.chemrev.6b00369. Epub 2016 Sep 29.
Advanced drug delivery systems (DDS) enhance treatment efficacy of different therapeutics in a dosage, spatial, and/or temporal controlled manner. To date, numerous chemical- or physical-based stimuli-responsive formulations or devices for controlled drug release have been developed. Among them, the emerging mechanical force-based stimulus offers a convenient and robust controlled drug release platform and has attracted increasing attention. The relevant DDS can be activated to promote drug release by different types of mechanical stimuli, including compressive force, tensile force, and shear force as well as indirect formats, remotely triggered by ultrasound and magnetic field. In this review, we provide an overview of recent advances in mechanically activated DDS. The opportunities and challenges regarding clinical translations are also discussed.
先进的药物输送系统（DDS）以剂量、空间和/或时间控制的方式增强了不同治疗药物的治疗效果。迄今为止，已经开发出许多基于化学或物理的刺激响应制剂或装置来控制药物释放。其中，新兴的机械力刺激提供了一个方便且强大的控制药物释放平台，引起了越来越多的关注。相关的 DDS 可以通过不同类型的机械刺激（包括压力、拉力和剪切力以及间接形式，如超声和磁场远程触发）激活以促进药物释放。在本综述中，我们概述了机械激活 DDS 的最新进展。还讨论了临床转化的机遇和挑战。
