Singuru Murali Mohana Rao, Amouzadeh Tabrizi Mahmoud, Bhattacharyya Priyanka, Ali Ahsan Ausaf, You Mingxu
Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Nano Lett. 2025 Jan 8;25(1):336-342. doi: 10.1021/acs.nanolett.4c05076. Epub 2024 Dec 24.
Cellular mechanical dysregulation can lead to diseases and conditions like tumorigenesis. Drug delivery systems that recognize and respond to specific cellular mechanical characteristics are potentially useful for targeted therapy. We report here the creation of a DNA mechanical nanovehicle that is responsive to cell surface receptor-mediated tensile forces, which can then correspondingly deliver an anticancer drug in situ. These DNA mechanical nanovehicles can spontaneously anchor onto cell membranes and enable the real-time visualization of molecular tensions at intercellular junctions. Once a strong intercellular force was detected, a rapid drug release event was followed automatically. Force-triggered targeted cancer cell treatment was demonstrated both in vitro and in a cell mixture. Our results proved a novel cellular force-responsive platform that can be used for highly specific drug delivery, which may potentially lead to smart cancer therapy with enhanced efficacy and safety.
细胞机械调节异常可导致肿瘤发生等疾病和病症。识别并响应特定细胞机械特性的药物递送系统可能对靶向治疗有用。我们在此报告了一种DNA机械纳米载体的创建，该载体对细胞表面受体介导的拉力有响应，进而能够原位相应地递送抗癌药物。这些DNA机械纳米载体可自发锚定在细胞膜上，并能实时可视化细胞间连接处的分子张力。一旦检测到强大的细胞间力，随后会自动发生快速药物释放事件。在体外和细胞混合物中均证明了力触发的靶向癌细胞治疗。我们的结果证明了一种新型的细胞力响应平台，可用于高度特异性的药物递送，这可能潜在地导致具有更高疗效和安全性的智能癌症治疗。
