Sterkenburg Anthe S, Hoffmann Anika, Reichel Julia, Lohle Kristin, Eveslage Maria, Warmuth-Metz Monika, Müller Hermann L
Department of Pediatrics (A.S.S., A.H., J.R., K.L., H.L.M.), Klinikum Oldenburg AöR, Medical Campus University Oldenburg, 26133 Oldenburg, Germany; University of Groningen (A.S.S.), 9700 Groningen, The Netherlands; Institute of Biostatistics and Clinical Research (M.E.), University of Münster, 48149 Münster, Germany; and Department of Neuroradiology (M.W.-M.), University Hospital, 97080 Würzburg, Germany.
J Clin Endocrinol Metab. 2016 Dec;101(12):4922-4930. doi: 10.1210/jc.2016-2547. Epub 2016 Sep 28.
Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.
The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.
This was a cross-sectional and longitudinal prospective study in CP patients.
The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.
Participants included 94 CP patients and 75 controls.
There were no interventions.
Association of NST with BC and BP in 43 CP and 43 controls was measured.
NST correlated with BMI SD score (SDS; r = 0.78; P < .001; n = 169) and WHtR (r = 0.85; P < .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P < .001, n = 94); NST-WHtR: r = 0.835, P < .001, n=43) and controls (NST-BMI SDS: r = 0.792, P < .001, n = 75; NST-WHtR: r = 0.671, P < .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P < .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P < .001) and WHtR (P = .01) but not with changes in BP and functional capacity.
Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.
下丘脑性肥胖、心血管疾病（CVD）以及复发/进展对儿童期颅咽管瘤（CP）的预后有重大影响。我们分析了用于随访监测的磁共振成像上的颈部皮褶厚度（NST），将其作为CP中身体成分（BC）和CVD的一个新参数。
本研究的目的是确定CP患者及对照组中NST与体重指数（BMI）、腰高比（WHtR）、功能能力和血压（BP）之间的关联。
这是一项针对CP患者的横断面和纵向前瞻性研究。
该研究在HIT-Endo、KRANIOPHARYNGEOM 2000/2007进行。
参与者包括94例CP患者和75名对照。
无干预措施。
测量了43例CP患者和43名对照中NST与BC和BP的关联。
在整个队列和CP患者中，NST与BMI标准差评分（SDS；r = 0.78；P <.001；n = 169）和WHtR（r = 0.85；P <.001；n = 86）相关；在CP患者中（NST-BMI SDS：r = 0.77，P <.001，n = 94）；NST-WHtR：r = 0.835，P <.001，n = 43），在对照组中（NST-BMI SDS：r = 0.792，P <.001，n = 75；NST-WHtR：r = 0.671，P <.001，n = 43）。在CP中，收缩压与NST（r = 0.575，P <.001）、BMI SDS（r = 0.434，P =.004）和WHtR（r = 0.386，P =.011）相关。CP患者的舒张压也观察到类似结果。在多变量分析中，NST对青春期后CP患者和对照组的高血压具有预测价值（比值比6.98，95%置信区间[1.65，29.5]，P =.008）。在纵向随访期间，NST的变化与BMI SDS（P <.001）和WHtR（P =.01）的变化相关，但与BP和功能能力的变化无关。
由于磁共振成像和BC监测对CP的随访至关重要，NST可作为CP中BC和CVD风险纵向评估的一个新的且具有临床相关性的参数。
