Balazard F, Le Fur S, Valtat S, Valleron A J, Bougnères P, Thevenieau Dominique, Chatel Corinne Fourmy, Desailloud Rachel, Bony-Trifunovic Hélène, Ducluzeau Pierre-Henri, Coutant Régis, Caudrelier Sophie, Pambou Armelle, Dubosclard Emmanuelle, Joubert Florence, Jan Philippe, Marcoux Estelle, Bertrand Anne-Marie, Mignot Brigitte, Penformis Alfred, Stuckens Chantal, Piquemal Régis, Barat Pascal, Rigalleau Vincent, Stheneur Chantal, Fournier Sylviane, Kerlan Véronique, Metz Chantal, Fargeot-Espaliat Anne, Reznic Yves, Olivier Frédérique, Gueorguieva Iva, Monier Arnaud, Radet Catherine, Gajdos Vincent, Terral Daniel, Vervel Christine, Bendifallah Djamel, Signor Candace Ben, Dervaux Daniel, Benmahammed Abdelkader, Loeuille Guy-André, Popelard Françoise, Guillou Agnès, Benhamou Pierre-Yves, Khoury Jamil, Brossier Jean-Pierre, Bassil Joachim, Clavel Sylvaine, Le Luyer Bernard, Bougnères Pierre, Labay Françoise, Guemas Isabelle, Weill Jacques, Cappoen Jean-Pierre, Nadalon Sylvie, Lienhardt-Roussie Anne, Paoli Anne, Kerouedan Claudie, Yollin Edwige, Nicolino Marc, Simonin Gilbert, Cohen Jacques, Atlan Catherine, Tamboura Agnès, Dubourg Hervé, Pignol Marie-Laure, Talon Philippe, Jellimann Stéphanie, Chaillous Lucy, Baron Sabine, Bortoluzzi Marie-Noëlle, Baechler Elisabeth, Salet Randa, Zelinsky-Gurung Ariane, Dallavale Fabienne, Larger Etienne, Laloi-Michelin Marie, Gautier Jean-François, Guérin Bénédicte, Oilleau Laure, Pantalone Laetitia, Lukas Céline, Guilhem Isabelle, De Kerdanet Marc, Wielickzo Marie-Claire, Priou-Guesdon Mélanie, Richard Odile, Kurtz François, Laisney Norbert, Ancelle Déborah, Parlier Guilhem, Boniface Catherine, Bockel Dominique Paris, Dufillot Denis, Razafimahefa Berthe, Gourdy Pierre, Lecomte Pierre, Pepin-Donat Myriam, Combes-Moukhovsky Marie-Emmanuelle, Zymmermann Brigitte, Raoulx Marina, Dumont Anne Gourdin Et Catherine
Sorbonne Universités, UPMC Univ Paris 06, CNRS, Paris, France.
INSERM U1169, Hôpital Bicêtre, Université Paris-Sud, Kremlin-Bicêtre, France.
BMC Public Health. 2016 Sep 29;16(1):1021. doi: 10.1186/s12889-016-3690-9.
The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D.
Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child's environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods.
We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age.
The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas.
Clinical-Trial.gov NCT02212522 . Registered August 6, 2014.
在许多国家，儿童1型糖尿病（T1D）的发病率正在上升，据推测这是由于环境因素的变化，但这些因素在很大程度上尚不清楚。本研究的目的是找出与T1D相关的环境标志物。
病例来自法国伊西斯糖尿病队列中的T1D患儿。对照为患者的同学或朋友。要求家长填写一份845项的问卷，调查孩子在诊断前的环境。分析考虑了病例与对照之间的匹配情况。第二次分析采用倾向评分法。
我们发现几种生活方式变量、肠胃炎发作、口腔卫生、榛子可可酱消费、黄蜂和蜜蜂蜇伤与T1D呈负相关，食用农场蔬菜以及宠物高龄死亡也与之呈负相关。
新发现的环境标志物与T1D之间的统计学关联需要在其他队列中进行重复验证，并对新的环境领域进行研究。
Clinical-Trial.gov NCT02212522。于2014年8月6日注册。
