Fulgheri Gabriele, Malinowski Bartosz
PhD students, Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
EJIFCC. 2011 Oct 5;22(3):79-91. eCollection 2011 Oct.
Interleukin-33 (IL-33) is a newly found cytokine of the interleukin-1 (IL-1) family. It's mainly expressed by epithelial and endothelial cells. This expression is upregulated by pro-inflammatory stimulation, thus has an important role in inflammatory responses, such as hypersensitive diseases (asthma), autoimmune diseases (rheumatoid arthritis), cardiovascular diseases (heart failure) and neurodegenerative diseases (Alzheimer). Several studies explored the complicated mechanism of IL-33 action in asthma and atherosclerosis, as this IL is significantly increased in these pathologies, and suggested its potential use in the therapeutic procedures.
白细胞介素-33（IL-33）是白细胞介素-1（IL-1）家族新发现的一种细胞因子。它主要由上皮细胞和内皮细胞表达。这种表达在促炎刺激下上调，因此在炎症反应中起重要作用，如过敏性疾病（哮喘）、自身免疫性疾病（类风湿性关节炎）、心血管疾病（心力衰竭）和神经退行性疾病（阿尔茨海默病）。一些研究探讨了IL-33在哮喘和动脉粥样硬化中作用的复杂机制，因为这种白细胞介素在这些病症中显著增加，并提示了其在治疗过程中的潜在用途。
