白细胞介素-33：一种新型的中介分子，在不同疾病的病理中发挥作用。
Interleukin-33: a novel mediator with a role in distinct disease pathologies.
机构信息
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
出版信息
J Intern Med. 2011 Jan;269(1):29-35. doi: 10.1111/j.1365-2796.2010.02316.x.
Interleukin-33 (IL-33) is a novel member of IL-1 cytokine family. It can act both as a nuclear factor and as a soluble mediator; however, the precise role of IL-33 within the nucleus is still not clear. As a cytokine, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage. As such, IL-33 targets multiple cell types thereby alerting the immune system to endogenous trauma such as physical stress or infection. However, a dysregulated release of IL-33 has a potential to drive distinct pathologies. In this review, we discuss the contribution of IL-33 to the pathophysiology of asthma, arthritis, obesity and atherosclerosis as well as the potential of IL-33 for therapeutic intervention.
白细胞介素 33（IL-33）是白细胞介素 1 细胞因子家族的一种新型成员。它既可以作为核因子，也可以作为可溶性介质发挥作用；然而，IL-33 在核内的确切作用仍不清楚。作为一种细胞因子，IL-33 被认为是一种警报素，在血管内皮细胞或上皮细胞受损时释放。因此，IL-33 靶向多种细胞类型，从而提醒免疫系统注意内源性创伤，如身体应激或感染。然而，IL-33 的失调释放有可能导致不同的病理。在这篇综述中，我们讨论了 IL-33 对哮喘、关节炎、肥胖症和动脉粥样硬化的病理生理学的贡献，以及 IL-33 用于治疗干预的潜力。
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