Latini Roberto, Masson Serge
Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" , Milan, Italy.
EJIFCC. 2013 Feb 21;24(3):78-84. eCollection 2013 Feb.
N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is a versatile biomarker, that has been extensively studied in large cohorts of individuals in the general population, in subjects at risk for developing left ventricular dysfunction and cardiovascular events, and in patients with chronic or acutely decompensated heart failure (HF). In this paper, the pros and cons of using natriuretic peptide testing to manage patients with HF are presented and discussed over 3 broad areas: (1) dyspnea triage in the emergency room, (2) natriuretic peptide-guided treatment of chronic HF, and (3) management of patients with HF in primary care and nursing homes.
脑钠肽前体N端（NT-proBNP）是一种多功能生物标志物，已在普通人群的大量个体队列、有发生左心室功能障碍和心血管事件风险的受试者以及慢性或急性失代偿性心力衰竭（HF）患者中进行了广泛研究。本文在三个广泛领域介绍并讨论了使用利钠肽检测来管理HF患者的利弊：（1）急诊室的呼吸困难分诊，（2）利钠肽指导的慢性HF治疗，以及（3）初级保健和疗养院中HF患者的管理。
