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急性血流导向装置治疗破裂夹层动脉瘤中仅使用阿司匹林作为单一口服抗血小板治疗。

Use of aspirin as sole oral antiplatelet therapy in acute flow diversion for ruptured dissecting aneurysms.

机构信息

Department of Interventional Neuroradiology, Institute of Neurological Sciences, Prince of Wales Hospital and Community Health Services, Randwick, New South Wales, Australia.

Prince of Wales Clinical School, University of New South Wales, Randwick, Australia.

出版信息

J Neurointerv Surg. 2017 May;9(5):e18. doi: 10.1136/neurintsurg-2016-012657.rep. Epub 2016 Sep 28.

Abstract

Subarachnoid hemorrhage secondary to rupture of a circumferential dissecting aneurysm continues to be a treatment dilemma. Vessel sacrifice, when possible, continues to be the safest option but in certain cases this is not possible due to lack of collateral supply. In such cases, coil assisted endovascular flow diversion has become a potential option but the requirement for dual antiplatelet therapy in an unsecured intracranial aneurysm continues to raise concern.We present a 48-year-old man with a World Federation of Neurological Surgeons grade 5 subarachnoid hemorrhage, secondary to a ruptured intradural left vertebral artery dissecting aneurysm, who was treated successfully with a pipeline embolization device with Shield technology using aspirin and a single intravenous loading dose of abciximab. To our knowledge, this is the first case of an acute flow diversion performed using only aspirin as the sole oral antiplatelet agent.

摘要

蛛网膜下腔出血继发于环形夹层动脉瘤破裂仍然是一个治疗难题。在可能的情况下,血管牺牲仍然是最安全的选择,但在某些情况下,由于缺乏侧支供应,这是不可能的。在这种情况下,线圈辅助的血管内血流转向已成为一种潜在的选择,但在未固定的颅内动脉瘤中使用双联抗血小板治疗仍然引起关注。我们报告了一例 48 岁男性,因颅内左椎动脉夹层动脉瘤破裂导致世界神经外科学会 5 级蛛网膜下腔出血,成功地使用具有 Shield 技术的 Pipeline 栓塞装置进行治疗,该装置使用阿司匹林和单次静脉负荷剂量的阿昔单抗。据我们所知,这是首例仅使用阿司匹林作为单一口服抗血小板药物进行的急性血流转向术。

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