美国首次使用带有屏蔽技术的Pipeline Flex并以阿司匹林作为抗血小板单一疗法的经验。
First US experience with Pipeline Flex with Shield Technology using aspirin as antiplatelet monotherapy.
作者信息
Hanel Ricardo A, Aguilar-Salinas Pedro, Brasiliense Leonardo Bc, Sauvageau Eric
机构信息
Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA.
Division of Neurosurgery, University of Arizona, Tucson, Arizona, USA.
出版信息
BMJ Case Rep. 2017 May 4;2017:bcr-2017-219406. doi: 10.1136/bcr-2017-219406.
Abstract
Flow diversion has revolutionised the treatment of intracranial aneurysms, and the Pipeline Embolization Device (PED) remains the only flow diverter (FD) approved in the USA. However, thromboembolic events remain an issue for FDs. Attempting to minimise these incidents, a newer PED has been developed with the use of covalent bonding of phosphorylcholine onto the Pipeline device that has been known as Shield Technology (PED Shield), which in vitro has demonstrated a significant reduction in material thrombogenicity. We report the first US experience of the PED Shield in the treatment of a ruptured fusiform aneurysm located in the right vertebral artery in an attempt to mitigate complications related to the use of dual-antiplatelet therapy and discuss our rationale for using the new FD, using aspirin only as the antiplatelet regimen.
摘要
血流导向已彻底改变了颅内动脉瘤的治疗方式，而Pipeline栓塞装置（PED）仍是美国唯一获批的血流导向装置（FD）。然而，血栓栓塞事件仍是FD面临的一个问题。为尽量减少这些事件，一种新型PED已被研发出来，它通过将磷酰胆碱共价结合到Pipeline装置上制成，即所谓的Shield技术（PED Shield），体外实验已证明该材料的血栓形成性显著降低。我们报告了美国首例使用PED Shield治疗位于右侧椎动脉的破裂梭形动脉瘤的经验，旨在减轻与双联抗血小板治疗相关的并发症，并讨论我们仅使用阿司匹林作为抗血小板方案而采用新型FD的理由。
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