a Department of Medicine, Division of Tropical Medicine and Infectious Diseases , University of Rostock Medical School , Rostock , Germany.
b Department of Medicine, Division of Nephrology , University of Rostock Medical School , Rostock , Germany.
Infect Dis (Lond). 2017 Feb;49(2):132-136. doi: 10.1080/23744235.2016.1225980. Epub 2016 Sep 29.
Haemodialysis patients have been found to have an increased risk of developing Pneumocystis pneumonia (PcP) compared to the control population. To the best of our knowledge, no data are available on pulmonary colonization with Pneumocystis jirovecii in haemodialysis patients; therefore, the aim of this study was to determine the prevalence of pulmonary colonization with P. jirovecii in haemodialysis patients, and to find the related risk factors. Induced sputa of 62 haemodialysis patients were investigated using quantitative polymerase chain reaction for the presence of P. jirovecii. 20.9% of the patients were colonized with P. jirovecii and 46.2% of whom had CD4 cell counts below 400/μl. There was no significant correlation between colonization and time on dialysis treatment. As haemodialysis patients seem to be at higher risk of PcP than the general population, doctors should be aware of the high rate of P. jirovecii colonization amongst them. Furthermore, colonized patients remain a potential source of transmission of P. jirovecii to other patients or to health care workers.
与对照人群相比，血液透析患者被发现发生肺囊虫肺炎（PcP）的风险增加。据我们所知，目前尚无血液透析患者肺部肺孢子菌定植的数据；因此，本研究旨在确定血液透析患者肺部肺孢子菌定植的流行率，并寻找相关的危险因素。使用定量聚合酶链反应检测 62 例血液透析患者的诱导痰中是否存在肺孢子菌。20.9%的患者肺部定植了肺孢子菌，其中 46.2%的患者 CD4 细胞计数低于 400/μl。定植与透析治疗时间之间无显著相关性。由于血液透析患者发生 PcP 的风险似乎高于普通人群，因此医生应注意他们中肺孢子菌定植的高比率。此外，定植的患者仍然是向其他患者或医护人员传播肺孢子菌的潜在传染源。
