Hays T R, Lin S H, Eyring H
Proc Natl Acad Sci U S A. 1978 May;75(5):2064-8. doi: 10.1073/pnas.75.5.2064.
The membrane model previously described [Hays, T.R., Buckwalter, C.Q., Lin S.H. & Eyring, H. (1978) Proc. Natl. Acad. Sci. USA 75, 1612-1615] for ion flow through a membrane is expanded to include the effect of binding of the mobile ion at the occupiable sites in the membrane. Two different effects were investigated: alteration of the association-dissociation rates at constant equilibrium constant and alteration of the equilibrium constant at constant dissociation constant. Increasing the rates of association and dissociation initially causes an increased slowing of the relaxation to the final steady state, though ultimately the curves for the faster rates cross those for the slower states. Increasing the equilibrium constant causes a greater delay in the relaxation curve, with the curves for different equilibrium constants not crossing. Overall, the effect of binding is not very great unless the equilibrium constant for binding is quite large.
先前描述的[海斯，T.R.，巴克沃尔特，C.Q.，林S.H.和艾林，H.（1978年）《美国国家科学院院刊》75，1612 - 1615]关于离子通过膜流动的膜模型被扩展，以包括可移动离子在膜中可占据位点处结合的影响。研究了两种不同的效应：在恒定平衡常数下缔合 - 解离速率的改变以及在恒定解离常数下平衡常数的改变。缔合和解离速率的增加最初会导致弛豫到最终稳态的速度增加变慢，不过最终较快速率的曲线会与较慢速率的曲线交叉。平衡常数的增加会导致弛豫曲线有更大的延迟，不同平衡常数的曲线不会交叉。总体而言，除非结合的平衡常数相当大，否则结合的影响不是很大。
