Aizenbud B M, Gershon N D
Biophys J. 1985 Oct;48(4):543-6. doi: 10.1016/S0006-3495(85)83811-X.
Molecules diffusing on nonplanar membranes, which have different amounts of corrugation in different directions, may experience dissimilar diffusion coefficients in each direction. Smith et al. (1979, Proc. Natl. Acad. Sci. USA, 76:5641-5644) measured diffusion anisotropy on fibroblast cell membranes in which the ratio of the diffusion coefficients, in different directions, was 0.27. In the present work we calculate the effect of anisotropic corrugation on the rate of diffusion of molecules on membranes. We find that part of the anisotropy reported by Smith et al. (1979, Proc. Natl. Acad. Sci. USA, 76:5641-5644) can be explained by the membrane nonplanarity, and we present the way of calculating this geometric factor.
在非平面膜上扩散的分子，在不同方向上具有不同程度的波纹，可能在每个方向上经历不同的扩散系数。史密斯等人（1979年，《美国国家科学院院刊》，76:5641 - 5644）测量了成纤维细胞膜上的扩散各向异性，其中不同方向上的扩散系数之比为0.27。在本研究中，我们计算了各向异性波纹对膜上分子扩散速率的影响。我们发现，史密斯等人（1979年，《美国国家科学院院刊》，76:5641 - 5644）报告的部分各向异性可以用膜的非平面性来解释，并且我们给出了计算这个几何因子的方法。
