Barbas H, Pandya D N
Department of Health Sciences, Boston University, Massachusetts 02215.
J Comp Neurol. 1989 Aug 15;286(3):353-75. doi: 10.1002/cne.902860306.
An investigation of the architectonic organization and intrinsic connections of the prefrontal cortex was conducted in rhesus monkeys. Cytoarchitectonic analysis indicates that in the prefrontal cortex there are two trends of gradual change in laminar characteristics that can be traced from limbic periallocortex towards isocortical areas. The stepwise change in laminar features is characterized by the emergence and gradual increase in the width of granular layer IV, by an increase in the size of pyramidal cells in layers III and V, and by a higher cell-packing density in the supragranular layers. Myeloarchitectonic analysis reveals that the limbic areas are poorly myelinated, adjacent areas have a diffuse myelin content confined to the deep layers, and in isocortices the myelinated fibers are distributed in organized horizontal bands (of Bail-larger) and a vertical plexus. Using the above architectonic criteria, we observed that one of the architectonic trends takes a radial basoventral course from the periallocortex in the caudal orbitofrontal region to the adjacent proisocortex and then to area 13. The next stage of architectonic regions includes orbital areas 12, 11, and 14, which is followed by area 10, lateral area 12, and the rostral part of ventral area 46. The last group includes the caudal part of ventral area 46 and ventral area 8. The other trend takes a mediodorsal course from the periallocortex around the rostral portion of the corpus callosum to the adjacent proisocortical areas 24, 25, and 32 and then to the medially situated isocortical areas 9, 10, and 14. The next stage includes lateral areas 10 and 9 and the rostral part of dorsal area 46. The last group includes the caudal part of dorsal area 46 and dorsal area 8. The interconnections of subdivisions of the basoventral and mediodorsal cortices were studied with the aid of anterograde and retrograde tracers. Within each trend a given area projects in two directions: to adjoining regions belonging to succeeding architectonic stages on the one hand, and to nearby regions from the preceding architectonic stage on the other. In each direction there is more than one region involved in this projection system, paralleling the radial nature of architectonic change. Periallo- and proisocortices have widespread intrinsic connections, whereas isocortices situated at a distance from limbic areas, such as area 8, have restricted connections. Most interconnections are limited to areas within the same architectonic trend. However, there are links between cortices from the two trends, and these seem to occur between areas that are at a similar stage of architectonic differentiation.(ABSTRACT TRUNCATED AT 400 WORDS)
我们对恒河猴的前额叶皮层的结构组织和内在联系进行了研究。细胞结构分析表明，在前额叶皮层中，从边缘周皮质向同型皮质区域可追溯到两种层状特征逐渐变化的趋势。层状特征的逐步变化表现为颗粒层IV宽度的出现和逐渐增加、III层和V层锥体细胞大小的增加以及颗粒上层中更高的细胞堆积密度。髓鞘结构分析显示，边缘区域髓鞘化程度低，相邻区域有局限于深层的弥散性髓鞘成分，在同型皮质中，有髓纤维分布在有组织的水平带（贝亚尔较大带）和垂直丛中。根据上述结构标准，我们观察到一种结构趋势从尾侧眶额叶区域的周皮质呈放射状向腹侧走行至相邻的原同型皮质，然后到13区。结构区域的下一阶段包括眶区12、11和14，接着是10区、外侧12区和腹侧46区的嘴侧部分。最后一组包括腹侧46区的尾侧部分和腹侧8区。另一种趋势从胼胝体嘴侧部分周围的周皮质呈中背侧走行至相邻的原同型皮质区域24、25和32，然后到位于内侧的同型皮质区域9、10和14。下一阶段包括外侧10区和9区以及背侧46区的嘴侧部分。最后一组包括背侧46区的尾侧部分和背侧8区。借助顺行和逆行示踪剂研究了腹侧和中背侧皮质各亚区的相互联系。在每种趋势内，一个给定区域向两个方向投射：一方面投射到属于后续结构阶段的相邻区域，另一方面投射到来自前一结构阶段的附近区域。在每个方向上，这个投射系统涉及不止一个区域，这与结构变化的放射状性质平行。周皮质和原同型皮质有广泛的内在联系，而远离边缘区域的同型皮质，如8区，其联系有限。大多数相互联系限于同一结构趋势内的区域。然而，两种趋势的皮质之间存在联系，这些联系似乎发生在结构分化处于相似阶段的区域之间。（摘要截选至400词）
