Zubair M, Ahmad M, Saleemi M K, Gul S T, Ahmad N, Umar S
Department of Theriogenology, University of Agriculture, Faisalabad, Pakistan.
Department of Pathology, University of Agriculture, Faisalabad, Pakistan.
Andrologia. 2017 Sep;49(7). doi: 10.1111/and.12699. Epub 2016 Sep 29.
The objective of this study was to investigate the toxic effects of arsenic on testicular measurements and histology of adult Teddy goats bucks and to examine whether these toxic effects are scavenged by vitamin E. Twelve adult Teddy goat bucks were divided randomly into three groups, A, B and C. Group A was kept as control, the B was given sodium arsenite 5 mg/kg BW per day, and group C was fed with vitamin E 200 mg/kg BW per day + arsenic 5 mg/kg BW per day. This treatment was continued for 84 days. Analysis of data revealed that the testicular measurements (scrotal circumference, width, length and weight) were significantly reduced in arsenic-treated animals, whereas there were ameliorating effects of vitamin E on these parameters. The major histopathological changes were present in the form of loss of germinal epithelium, atrophy of Leydig cells and vacuolations. Vitamin E in combination with sodium arsenite increased the active spermatogenesis as well as restoration of germinal epithelium. It can be concluded from the present findings that sodium arsenite causes toxicity in the male reproductive system of Teddy goat bucks with major changes in parenchyma of testes. Supplementation of vitamin E has protective effects on the toxicity of sodium arsenite on the reproductive system of male Teddy goat bucks.
本研究的目的是调查砷对成年泰迪山羊公羊睾丸测量值和组织学的毒性作用，并检验这些毒性作用是否能被维生素E清除。将12只成年泰迪山羊公羊随机分为三组，A组、B组和C组。A组作为对照组，B组每天给予5毫克/千克体重的亚砷酸钠，C组每天饲喂200毫克/千克体重的维生素E + 5毫克/千克体重的砷。这种处理持续84天。数据分析显示，经砷处理的动物睾丸测量值（阴囊周长、宽度、长度和重量）显著降低，而维生素E对这些参数有改善作用。主要组织病理学变化表现为生发上皮丧失、睾丸间质细胞萎缩和空泡化。维生素E与亚砷酸钠联合使用可增加活跃的精子发生以及生发上皮的恢复。从目前的研究结果可以得出结论，亚砷酸钠会导致泰迪山羊公羊雄性生殖系统中毒，睾丸实质发生重大变化。补充维生素E对亚砷酸钠对雄性泰迪山羊公羊生殖系统的毒性具有保护作用。
