Kamran Kiran, Khan Muhammad Yunus, Minhas Liaqat Ali
Department of Anatomy, Fazaia Medical College, Air University, Islamabad.
Department of Anatomy, CPSP Regional Center, Islamabad, Pakistan.
J Pak Med Assoc. 2016 Oct;66(10):1227-1231.
To study the effects of ethanol vapour exposure on atrial and ventricular walls of heart in chick embryo.
The study design was experimental, conducted at Islamabad Centre of College of Physicians and Surgeons, Pakistan. One hundred and eighty chicken eggs were divided into two groups, experimental and control, of 90 eggs each. Each group was subdivided into three subgroups of 30 eggs each based on the day of sacrifice. Experimental group was exposed to ethanol vapours and then compared with age matched controls.
The thickness of atrial and ventricular walls along with lengths of valvular cusps increased in hearts of day 7 and day 10 chick embryos in experimental group. There was thinning of walls and decreased length of valvular cusps in hearts of experimental chicks on hatching as compared to age matched controls.
Ethanol vapour exposure during development causes cardiac and septal wall thickening during initial days of development followed by cardiac and septal wall thinning which is a classical picture of alcohol induced cardiomyopathies.
研究乙醇蒸汽暴露对鸡胚心脏心房和心室壁的影响。
本研究为实验性研究，在巴基斯坦伊斯兰堡内科医师与外科医师学院中心进行。180枚鸡蛋分为两组，实验组和对照组，每组90枚。根据处死日，每组再细分为三个亚组，每组30枚。实验组暴露于乙醇蒸汽中，然后与年龄匹配的对照组进行比较。
实验组第7天和第10天鸡胚心脏的心房和心室壁厚度以及瓣膜尖长度增加。与年龄匹配的对照组相比，实验组雏鸡孵化时心脏壁变薄，瓣膜尖长度缩短。
发育期间暴露于乙醇蒸汽会在发育初期导致心脏和间隔壁增厚，随后出现心脏和间隔壁变薄，这是酒精性心肌病的典型表现。
