Laky Markus, Bertl Kristina, Haririan Hady, Andrukhov Oleh, Seemann Rudolf, Volf Ivo, Assinger Alice, Gruber Reinhard, Moritz Andreas, Rausch-Fan Xiaohui
Division of Conservative Dentistry and Periodontology, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria.
Department of Periodontology, Faculty of Odontology, University of Malmö, Malmö, Sweden.
Clin Oral Investig. 2017 Jun;21(5):1553-1558. doi: 10.1007/s00784-016-1965-2. Epub 2016 Sep 29.
Vitamin D plays an essential role in bone metabolism as well as in immunity. Hence, it might affect the development and extent of periodontal disease. The aim of this study was the assessment of 25-hydroxyvitamin D (25(OH)D) status in periodontal disease.
Twenty-nine patients with severe periodontal disease and 29 healthy volunteers were recruited in this case-control-study. Serum 25(OH)D levels, Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP), Body Mass Index (BMI), and current smoking status and smoking history (packyears) were assessed in all participants. Serum 25(OH)D levels were compared between controls and cases. Multivariable logistic regression was used to determine the odds ratio (OR) and 95 % confidence interval (CI) for periodontal disease in 25(OH)D deficient probands.
Patients with periodontal disease presented a significantly higher proportion of deficient 25(OH)D levels (i.e., <50 nmol/l) compared to healthy controls (48 vs. 14 % respectively). The adjusted OR for periodontal disease with vitamin D deficiency was 1.5 (95 % CI, 1.13-1.98). No correlation between serum 25(OH)D levels and CAL, PPD, and BOP in the group with periodontal disease was found.
In this case-control-study 25(OH)D deficiency is significantly associated with periodontal disease.
The assessment of vitamin D levels in patients presenting with periodontal disease seems advisable, as vitamin D deficiency might be involved in the onset and progression of periodontal disease.
维生素D在骨代谢以及免疫方面发挥着重要作用。因此，它可能会影响牙周疾病的发生发展及严重程度。本研究旨在评估牙周疾病患者的25-羟基维生素D（25(OH)D）水平。
本病例对照研究招募了29例重度牙周疾病患者和29名健康志愿者。对所有参与者评估血清25(OH)D水平、牙周探诊深度（PPD）、临床附着水平（CAL）、探诊出血（BOP）、体重指数（BMI）以及当前吸烟状况和吸烟史（包年数）。比较对照组和病例组的血清25(OH)D水平。采用多变量逻辑回归确定25(OH)D缺乏的先证者患牙周疾病的比值比（OR）和95%置信区间（CI）。
与健康对照组相比，牙周疾病患者中25(OH)D水平缺乏（即<50 nmol/l）的比例显著更高（分别为48%和14%）。维生素D缺乏的牙周疾病校正OR为1.5（95% CI，1.13 - 1.98）。在牙周疾病组中，未发现血清25(OH)D水平与CAL、PPD和BOP之间存在相关性。
在本病例对照研究中，25(OH)D缺乏与牙周疾病显著相关。
对患有牙周疾病的患者评估维生素D水平似乎是可取的，因为维生素D缺乏可能参与了牙周疾病的发生和进展。
