Department of Stomatology, Beijing ChaoYang Hospital affiliated to Capital Medical University, Beijing, China.
J Clin Periodontol. 2012 Apr;39(4):350-6. doi: 10.1111/j.1600-051X.2012.01852.x. Epub 2012 Feb 1.
To evaluate the associations of serum 25-Hydroxyvitamin D [25(OH)D] levels with periodontal health and chronic obstructive pulmonary disease (COPD).
We conducted a case-control study of 193 COPD patients and 181 controls. Their periodontal status and lung function were examined, and serum 25(OH)D levels were measured.
Mean serum 25(OH)D concentrations were significantly lower in the COPD group than in the controls (32.1 versus 35.8 nmol/l; p = 0.002). Serum 25(OH)D concentrations were positively correlated with lung function among non-smokers and negatively correlated with plaque index (PLI) among former smokers. After adjustment for age, gender, body mass index, season and smoking status, periodontal indexes were significantly associated with serum 25(OH)D concentrations (number of remaining teeth among all groups; probing depth, clinical attachment level, bleeding index, PLI and alveolar bone loss among COPD group). Lower serum 25(OH)D concentrations were significantly associated with an increased risk of COPD among former smokers (Odd ratio 4.11; 95% confidence interval 1.47-11.5; p = 0.007) after adjustment for periodontal indexes and other variables.
Lower serum 25(OH)D concentrations were significantly associated with poor periodontal health and an increased risk of COPD.
评估血清 25-羟维生素 D [25(OH)D]水平与牙周健康和慢性阻塞性肺疾病（COPD）的相关性。
我们进行了一项病例对照研究，共纳入 193 例 COPD 患者和 181 例对照。检查了他们的牙周状况和肺功能，并测量了血清 25(OH)D 水平。
COPD 组的平均血清 25(OH)D 浓度明显低于对照组（32.1 与 35.8 nmol/L；p=0.002）。血清 25(OH)D 浓度与非吸烟者的肺功能呈正相关，与前吸烟者的菌斑指数（PLI）呈负相关。在校正年龄、性别、体重指数、季节和吸烟状态后，牙周指数与血清 25(OH)D 浓度显著相关（所有组的剩余牙齿数；COPD 组的探诊深度、临床附着水平、出血指数、PLI 和牙槽骨丧失）。在校正牙周指数和其他变量后，较低的血清 25(OH)D 浓度与前吸烟者 COPD 的发病风险增加显著相关（比值比 4.11；95%置信区间 1.47-11.5；p=0.007）。
较低的血清 25(OH)D 浓度与较差的牙周健康和 COPD 的发病风险增加显著相关。
