病态肥胖所致慢性淋巴水肿背景下发生的血管肉瘤中的MYC扩增
MYC amplification in angiosarcomas arising in the setting of chronic lymphedema of morbid obesity.
作者信息
Harker David, Jennings Michael, McDonough Patrick, Mauskar Melissa, Savory Stephanie, Hosler Gregory A, Vandergriff Travis
机构信息
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Paul L. Foster School of Medicine, El Paso, TX, USA.
出版信息
J Cutan Pathol. 2017 Jan;44(1):15-19. doi: 10.1111/cup.12827. Epub 2016 Oct 21.
BACKGROUND
Angiosarcoma is a malignancy of vascular endothelial cells which may arise secondarily as a complication of lymphedema, including chronic lymphedema of morbid obesity. Amplifications in MYC are frequently present in secondary angiosarcoma (arising in irradiated sites and chronic lymphedema) and less frequently in primary cutaneous angiosarcoma.
OBJECTIVE
To describe the presence of MYC amplifications in two cases of cutaneous angiosarcoma secondary to chronic lymphedema of morbid obesity.
METHODS
This study is a case series of two patients with cutaneous angiosarcoma. Clinical data was retrieved from the medical records. Histopathological analysis of the biopsy specimens was performed, including immunohistochemistry, along with fluorescence in situ hybridization.
RESULTS
Angiosarcoma arose in the setting of massive chronic lymphedema complicating morbid obesity without other predisposing risk factors. Both cases exhibited epithelioid cell morphology and high-level MYC amplification.
CONCLUSION
We report MYC amplification in two cases of angiosarcoma arising in massive chronic lymphedema of morbid obesity.
背景
血管肉瘤是一种血管内皮细胞的恶性肿瘤，可继发于淋巴水肿，包括病态肥胖引起的慢性淋巴水肿。MYC基因扩增在继发性血管肉瘤（发生于放疗部位和慢性淋巴水肿）中较为常见，而在原发性皮肤血管肉瘤中较少见。
目的
描述两例病态肥胖所致慢性淋巴水肿继发皮肤血管肉瘤中MYC基因扩增的情况。
方法
本研究为两例皮肤血管肉瘤患者的病例系列。从病历中获取临床资料。对活检标本进行组织病理学分析，包括免疫组织化学以及荧光原位杂交。
结果
血管肉瘤发生于病态肥胖合并的大量慢性淋巴水肿背景下，无其他易感危险因素。两例均表现为上皮样细胞形态和高水平的MYC基因扩增。
结论
我们报告了两例病态肥胖所致大量慢性淋巴水肿继发血管肉瘤中存在MYC基因扩增。
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