Abtahi J, Henefalk G, Aspenberg P
Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping, Sweden; Department of Oral and Maxillofacial Surgery, Linköping University Hospital, Linköping, Sweden.
Department of Oral and Maxillofacial Surgery, Linköping University Hospital, Linköping, Sweden.
Int J Oral Maxillofac Surg. 2016 Dec;45(12):1564-1569. doi: 10.1016/j.ijom.2016.09.001. Epub 2016 Sep 26.
The results of a randomised trial with bisphosphonate-coated dental implants have been reported previously. Each patient received one coated and one uncoated implant in a double-blind split-mouth design study. After 6 months of osseointegration, resonance frequency analysis indicated better fixation of the coated implants. Reduced marginal bone resorption was also shown. However, it was not known whether the advantage of the bisphosphonate coating would persist over time. The radiographic results at 5 years after implant installation are reported herein. A blinded investigator measured marginal resorption on fresh radiographs obtained for 14 of the 16 patients (two had died) and compared these with the post-implantation images. Non-parametric statistics were used. All implants functioned well. The median marginal bone loss for control implants was found to be 0.70mm, which is less than usually reported in the literature. The bisphosphonate-coated implants showed even less resorption (median 0.20mm). The median difference within each pair of implants after 5 years of use was 0.34mm (95% confidence interval 0.00-0.75mm; P=0.04). The present data suggest that bisphosphonate-coated implants enable prolonged preservation of the marginal bone.
此前已有关于双膦酸盐涂层牙种植体随机试验的结果报道。在一项双盲分口设计研究中，每位患者均植入一枚涂层种植体和一枚未涂层种植体。骨整合6个月后，共振频率分析表明涂层种植体的固定效果更佳，边缘骨吸收也有所减少。然而，双膦酸盐涂层的优势是否会随时间持续尚不清楚。本文报告了种植体植入5年后的影像学结果。一名盲法研究者在为16名患者中的14名（两名已死亡）获取的新鲜X光片上测量边缘骨吸收情况，并将其与植入后的影像进行比较。采用非参数统计方法。所有种植体功能良好。对照种植体的边缘骨丢失中位数为0.70mm，低于文献中通常报道的数值。双膦酸盐涂层种植体的骨吸收甚至更少（中位数为0.20mm）。使用5年后，每对种植体的中位数差异为0.34mm（95%置信区间0.00 - 0.75mm；P = 0.04）。目前的数据表明，双膦酸盐涂层种植体能够长期保持边缘骨。
