Department of Oral and Maxillofacial Surgery, University of Heidelberg, Heidelberg, Germany.
Clin Oral Implants Res. 2011 Dec;22(12):1354-60. doi: 10.1111/j.1600-0501.2010.02123.x. Epub 2011 Mar 8.
Multiple experimental and animal studies have shown that topographic, mechanical and chemical properties of implant surfaces lead to in vivo responses such as increased bone formation, increased bone anchorage and reduced healing time. A fluoride modification of the titanium implant surface also seems to positively influence bone anchorage as compared with unmodified titanium implants. Using implant survival and marginal bone loss as primary outcome parameters, the purpose of the present prospective study was to investigate whether a fluoride modification of the titanium implant surface has positive clinical effects.
The 17 patients included in this study received 49 Astra Tech OsseoSpeed implants for various indications in the maxilla and mandible. Implants were either loaded immediately or after a mean healing period of 9.56 weeks. Fifteen patients were followed up clinically including radiographic examination for 5 years. Forty-two implants were assessed for implant survival, marginal bone loss, surgical and/or prosthetic complications, presence or absence of plaque, signs of inflammation and size of the papilla.
Of the original 17 patients, 15 patients were available for the full 60-month follow-up. One early implant failure occurred, leading to an implant survival rate of 97%. Radiographic analyses demonstrated stable bone conditions with a mean marginal bone loss of 0.1 mm (SD 0.4 mm, min -0.7 mm, max 1.7 mm) after 5 years of function. Immediately loaded implants did not show a different mean marginal bone loss as compared with implants that were not loaded immediately. Repeated soft-tissue examinations revealed healthy conditions in terms of 6.1% plaque and 4.2% of the implants with signs of inflammation at the 5-year control.
Implants used in this study had high survival and success rates after 5 years. Marginal bone was well maintained, irrespective of the loading regime.
多项实验和动物研究表明，种植体表面的地形、机械和化学特性会导致体内反应，如增加骨形成、增加骨锚固和缩短愈合时间。钛种植体表面的氟化物修饰似乎也能比未经修饰的钛种植体更积极地影响骨锚固。本前瞻性研究使用种植体存活率和边缘骨丧失作为主要结果参数，旨在探讨钛种植体表面的氟化物修饰是否具有积极的临床效果。
本研究纳入了 17 名患者，他们在上下颌接受了 49 颗 AstraTech OsseoSpeed 种植体，用于各种适应证。种植体要么立即负载，要么在平均 9.56 周的愈合期后负载。15 名患者接受了包括 5 年影像学检查在内的临床随访。42 颗种植体评估了种植体存活率、边缘骨丧失、手术和/或修复体并发症、菌斑的存在或不存在、炎症迹象和乳头大小。
在最初的 17 名患者中，有 15 名患者完成了 60 个月的完整随访。发生了 1 例早期种植体失败，导致种植体存活率为 97%。影像学分析显示，在 5 年的功能后，稳定的骨状况，平均边缘骨丧失为 0.1 毫米（标准差 0.4 毫米，最小值-0.7 毫米，最大值 1.7 毫米）。即刻负载的种植体与未即刻负载的种植体相比，其平均边缘骨丧失没有差异。重复的软组织检查显示，在 5 年的控制中，有 6.1%的菌斑和 4.2%的种植体有炎症迹象，健康状况良好。
本研究中使用的种植体在 5 年后具有较高的存活率和成功率。边缘骨保持良好，与负载方案无关。
