Narayana P L, Gupta A K, Sharma P K
Classified Specialist and HOD (Psychiatry), AFCME, Subroto Park, New Delhi-110010.
Classified Specialist (Psychiatry), Command Hospital (NC), Udhampur.
Med J Armed Forces India. 2008 Oct;64(4):320-4. doi: 10.1016/S0377-1237(08)80009-3. Epub 2011 Jul 21.
In a search for an effective 'anti-alcohol pill', three modern anti-craving agents have been studied in alcoholics of Army/ DSC, Air Force, Navy and Coast Guard.
129 patients of alcohol dependence syndrome were randomly assigned to three groups where topiramate, acamprosate and naltrexone were used as anti-craving agents in a year long prospective study. Of these 92 patients completed the study.
Topiramate (76.3%) appears to be significantly more effective (p<0.01) in sustaining abstinence, though naltrexone (57.7%) and acamprosate (60.70%) offer moderate relapse-prevention efficacy. Side effects of all the three agents have been mild, transient and self-limiting. We recommend a trial of topiramate, before invaliding out of any alcoholic soldier.
为寻找一种有效的“抗酒精药丸”，已在陆军/国防安全部队、空军、海军和海岸警卫队的酗酒者中对三种现代抗渴求药物进行了研究。
在一项为期一年的前瞻性研究中，将129例酒精依赖综合征患者随机分为三组，分别使用托吡酯、阿坎酸和纳曲酮作为抗渴求药物。其中92例患者完成了研究。
托吡酯（76.3%）在维持戒酒方面似乎明显更有效（p<0.01），尽管纳曲酮（57.7%）和阿坎酸（60.70%）具有中等程度的预防复发疗效。这三种药物的副作用均轻微、短暂且为自限性。我们建议在让任何酗酒士兵退役之前先试用托吡酯。
